Haematological effects of oral administration of bitopertin, a glycine transport inhibitor, in patients with non-transfusion-dependent β-thalassaemia

被引：15
|
作者：
Taher, Ali T. [1 ]
Viprakasit, Vip [2 ,3 ]
Cappellini, Maria Domenica [4 ]
Kraus, Dominik [5 ]
Cech, Patrick [5 ]
Volz, Dietmar [5 ]
Winter, Erica [6 ]
Nave, Stephane [5 ]
Dukart, Juergen [5 ,7 ,8 ]
Khwaja, Omar [5 ]
Koerner, Annette [5 ]
Hermosilla, Ricardo [5 ]
Brugnara, Carlo [9 ,10 ]
机构：
[1] Amer Univ Beirut, Med Ctr, Dept Internal Med, Div Hematol & Oncol, Beirut, Lebanon
[2] Mahidol Univ, Dept Pediat, Bangkok, Thailand
[3] Mahidol Univ, Div Hematol & Oncol, Siriraj Thalassemia Ctr, Bangkok, Thailand
[4] Univ Milan, Dept Med, CaGranda Fdn IRCCS, Milan, Italy
[5] Roche Innovat Ctr Basel, Roche Pharma Res & Early Dev, Basel, Switzerland
[6] Roche Innovat Ctr, Roche Pharma Res & Early Dev, New York, NY USA
[7] Res Ctr Julich, Inst Neurosci & Med Brain & Behav INM 7, Julich, Germany
[8] Heinrich Heine Univ Dusseldorf, Med Fac, Inst Syst Neurosci, Dusseldorf, Germany
[9] Boston Childrens Hosp, Dept Lab Med, Boston, MA USA
[10] Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2021年 / 194卷 / 02期
关键词：
bitopertin; haem; iron; reactive oxygen species; beta-thalassemia; ERYTHROPOIESIS;
D O I：
10.1111/bjh.17479
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：474 / 477
页数：4
相关论文
共 25 条
  • [1] When to consider transfusion therapy for patients with non-transfusion-dependent thalassaemia
    Taher, A. T.
    Radwan, A.
    Viprakasit, V.
    VOX SANGUINIS, 2015, 108 (01) : 1 - 10
  • [2] Role of platelets in thrombin generation amongst patients with non-transfusion-dependent thalassaemia
    Tan, Chuen Wen
    Wong, Wan Hui
    Idros, Roserahayu
    Chan, Yiong Huak
    Kaur, Hartirathpal
    Tng, Alvin Ren Kwang
    Lee, Lai Heng
    Ng, Heng Joo
    Ang, Ai Leen
    ANNALS OF HEMATOLOGY, 2019, 98 (04) : 861 - 868
  • [3] Magnitude of Bone Disease in Transfusion-Dependent and Non-Transfusion-Dependent β-Thalassemia Patients
    Shamoon, Rawand P.
    Yassin, Ahmed K.
    Omar, Negar
    Saeed, Muhammad D.
    Akram, Reving
    Othman, Naska N.
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (03)
  • [4] Treating iron overload in patients with non-transfusion-dependent thalassemia
    Taher, Ali T.
    Viprakasit, Vip
    Musallam, Khaled M.
    Cappellini, M. Domenica
    AMERICAN JOURNAL OF HEMATOLOGY, 2013, 88 (05) : 409 - 415
  • [5] Unexpected prevalence of hyperprolactinaemia associated with microprolactinoma and empty sella in a cohort of adult patients with non-transfusion-dependent thalassaemia: a prospective study
    Ricchi, Paolo
    Ammirabile, Massimiliano
    Spasiano, Anna
    Costantini, Silvia
    Vitale, Mario
    Di Matola, Tiziana
    Cinque, Patrizia
    Filosa, Aldo
    Serino, Domenico
    BRITISH JOURNAL OF HAEMATOLOGY, 2014, 164 (05) : 743 - 745
  • [6] Erythropoiesis and Iron Homeostasis in Non-Transfusion-Dependent Thalassemia Patients with Extramedullary Hematopoiesis
    Huang, Yumei
    Liu, Rongrong
    Wei, Xiaoyun
    Liu, Jiaodi
    Pan, Lingyuan
    Yang, Gaohui
    Lai, Yongrong
    BIOMED RESEARCH INTERNATIONAL, 2019, 2019
  • [7] Severe bacterial infections in patients with non-transfusion-dependent thalassemia: prevalence and clinical risk factors
    Teawtrakul, Nattiya
    Jetsrisuparb, Arunee
    Sirijerachai, Chittima
    Chansung, Kanchana
    Wanitpongpun, Chinadol
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2015, 39 : 53 - 56
  • [8] Anti-Mullerian Hormone Evaluates Ovarian Function in Patients with Non-Transfusion-Dependent Thalassemia
    Li, Yan
    Zhang, Xiangjun
    Yin, Xiaolin
    Fu, Zhenming
    Xie, Wen
    He, Xieyong
    Zhao, Yunxia
    Xiao, Yunshuo
    Yang, Kun
    Zhou, Yali
    Cheng, Shiwu
    MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2024, 17 (01)
  • [9] Defining serum ferritin thresholds to predict clinically relevant liver iron concentrations for guiding deferasirox therapy when MRI is unavailable in patients with non-transfusion-dependent thalassaemia
    Taher, Ali T.
    Porter, John B.
    Viprakasit, Vip
    Kattamis, Antonis
    Chuncharunee, Suporn
    Sutcharitchan, Pranee
    Siritanaratkul, Noppadol
    Origa, Raffaella
    Karakas, Zeynep
    Habr, Dany
    Zhu, Zewen
    Cappellini, Maria Domenica
    BRITISH JOURNAL OF HAEMATOLOGY, 2015, 168 (02) : 284 - 290
  • [10] Luspatercept for the treatment of anaemia in non-transfusion-dependent β-thalassaemia (BEYOND): a phase 2, randomised, double-blind, multicentre, placebo-controlled trial
    Taher, Ali T.
    Cappellini, Maria Domenica
    Kattamis, Antonis
    Voskaridou, Ersi
    Perrotta, Silverio
    Piga, Antonio G.
    Filosa, Aldo
    Porter, John B.
    Coates, Thomas D.
    Forni, Gian Luca
    Thompson, Alexis A.
    Tartaglione, Immacolata
    Musallam, Khaled M.
    Backstrom, Jay T.
    Esposito, Oriana
    Giuseppi, Ana Carolina
    Kuo, Wen-Ling
    Miteva, Dimana
    Lord-Bessen, Jennifer
    Yucel, Aylin
    Zinger, Tatiana
    Shetty, Jeevan K.
    Viprakasit, Vip
    LANCET HAEMATOLOGY, 2022, 9 (10): : E733 - E744
123