Testosterone's Role in COVID-19

被引：26

作者：

Auerbach, Jeremy M. ^{[1
]}

Khera, Mohit ^{[1
]}

机构：

[1] Baylor Coll Med, Scott Dept Urol, 7200 Cambridge,Suite 10B, Houston, TX 77030 USA

来源：

JOURNAL OF SEXUAL MEDICINE | 2021年 / 18卷 / 05期

关键词：

Coronavirus; Hypogonadism; Androgens; Immune System; Cytokines;

D O I：

10.1016/j.jsxm.2021.03.004

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

COVID-19 consistently displays a higher mortality in males. This sex-specific difference in outcomes is seen not only in the current COVID-19 pandemic, but also in prior viral epidemics and pandemics. Sex hormones, such as testosterone, play a clear role in modulating the immune response, providing a clue that may illuminate the underpinnings of these outcomes. Developing a deeper understanding of these epidemiological findings permits a more effective response to the disease. This article summarizes the sex-specific COVID-19 outcomes, the role of androgens in generating these outcomes, and the potential role of modifying testosterone levels as a form of treatment of COVID-19. Copyright Copyright (C) 2021, International Society of Sexual Medicine. Published by Elsevier Inc.

引用

页码：843 / 848

页数：6

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