Detecting oxidative post-translational modifications in proteins

被引：41
|
作者：
Gianazza, E.
Crawford, J.
Miller, I.
机构：
[1] Univ Milan, Dipartimento Sci Farmacol, Grp Studio Proteom & Struttura Prot, I-20133 Milan, Italy
[2] Nonlinear Dynam Ltd, Newcastle Upon Tyne, Tyne & Wear, England
[3] Vet Med Univ Wien, Inst Med Chem, Dept Nat Wissensch, Vienna, Austria
来源：
AMINO ACIDS | 2007年 / 33卷 / 01期
关键词：
oxidative post-translational modifications; proteomics; electrophoresis; carbonylation; glutathionylation;
D O I：
10.1007/s00726-006-0410-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxidative stress induces various post-translational modifications (PTM); some are reversible in vivo via enzymatic catalysis. The present paper reviews specific procedures for the detection of oxidative PTM in proteins, most of them including electrophoresis. Main topics are carbonylated and glutathionylated proteins as well as modification of selected amino acids ( Cys, Tyr, Met, Trp, Lys).
引用
收藏
页码：51 / 56
页数：6
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