Risk factors for venous thrombosis - current understanding from an epidemiological point of view

被引：162

作者：

Lijfering, Willem M. ^{[1
,2
]}

Rosendaal, Frits R. ^{[1
,3
]}

Cannegieter, Suzanne C. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Clin Epidemiol, NL-2300 RC Leiden, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Haematol, Div Haemostasis & Thrombosis, NL-9713 AV Groningen, Netherlands

[3] Leiden Univ, Med Ctr, Dept Thrombosis & Haemostasis, NL-2300 RC Leiden, Netherlands

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 149卷 / 06期

关键词：

venous thrombosis; risk factors; epidemiology; aetiology; thrombophilia; DEEP-VEIN THROMBOSIS; ARTERIAL THROMBOEMBOLIC EVENTS; CORONARY-HEART-DISEASE; ORAL-CONTRACEPTIVE USE; ACTIVATED PROTEIN-C; THROMBOPHILIC DEFECTS; PULMONARY-EMBOLISM; ANTIPHOSPHOLIPID ANTIBODIES; PROSPECTIVE-COHORT; REACTIVE PROTEIN;

D O I：

10.1111/j.1365-2141.2010.08206.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>Epidemiological research throughout the last 50 years has provided the long list of risk factors for venous thrombosis that are known today. Although this has advanced our current understanding about the aetiology of thrombosis, it does not give us all the answers: many people have several of these risk factors but never develop thrombosis; others suffer from thrombosis but have none. In this review, we discuss how risk factors for venous thrombosis can be interpreted with use of several epidemiological models. We comment on how to explain why risk factors for first venous thrombosis differ from recurrent venous thrombosis, and use a causal model to better understand risk of first and recurrent venous thrombosis.

引用

页码：824 / 833

页数：10

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