Progressive Multifocal Leukoencephalopathy After Allogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia

被引：4

作者：

Lee, Hans C. ^{[1
]}

Mulanovich, Victor ^{[2
]}

Nieto, Yago ^{[3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Div Canc Med, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular The, Houston, TX 77030 USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2014年 / 12卷 / 12期

关键词：

HEMATOPOIETIC-CELL TRANSPLANTATION; JC VIRUS; MEFLOQUINE TREATMENT; THERAPY; PATIENT; CYCLOPHOSPHAMIDE; POLYOMAVIRUS; COMPLICATION; MORTALITY; INFECTION;

D O I：

10.6004/jnccn.2014.0167

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Progressive multifocal leukoencephalopathy (PML) is a rare fatal complication of allogeneic bone marrow transplantation (BMT) resulting from chronic immunosuppression and impaired cellular immunity. This report discusses 2 cases of PML in patients with acute myeloid leukemia after allogeneic BMT. Diagnosis was made based on characteristic brain MRI findings and positive PCR results for John Cunningham virus in the cerebrospinal fluid. Unfortunately, therapeutic options are limited and nearly always result in terminal outcomes. Although immunosuppression is an unavoidable risk of allogeneic BMT, these cases highlight a rare, yet fatal, consequence of prolonged T-cell lymphopenia and impaired cellular immunity after allogeneic BMT in this patient population.

引用

页码：1660 / 1664

页数：5

共 42 条

[1] PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY - A HITHERTO UNRECOGNIZED COMPLICATION OF CHRONIC LYMPHATIC LEUKAEMIA AND HODGKINS DISEASE [J].

ASTROM, KE ;

MANCALL, EL ;

RICHARDSON, EP .

BRAIN, 1958, 81 (01) :93-&

[2] Polyomavirus JC-targeted T-cell therapy for progressive multiple leukoencephalopathy in a hematopoietic cell transplantation recipient [J].

Balduzzi, A. ;

Lucchini, G. ;

Hirsch, H. H. ;

Basso, S. ;

Cioni, M. ;

Rovelli, A. ;

Zincone, A. ;

Grimaldi, M. ;

Corti, P. ;

Bonanomi, S. ;

Biondi, A. ;

Locatelli, F. ;

Biagi, E. ;

Comoli, P. .

BONE MARROW TRANSPLANTATION, 2011, 46 (07) :987-992

[3] Human polyomavirus JC reactivation and pathogenetic mechanisms of progressive multifocal leukoencephalopathy and cancer in the era of monoclonal antibody therapies [J].

Bellizzi, A. ;

Nardis, C. ;

Anzivino, E. ;

Rodio, D. M. ;

Fioriti, D. ;

Mischitelli, M. ;

Chiarini, F. ;

Pietropaolo, V. .

JOURNAL OF NEUROVIROLOGY, 2012, 18 (01) :1-11

[4] Unusual Case of Progressive Multifocal Leukoencephalopathy After Allogeneic Hematopoietic Stem-Cell Transplantation [J].

Berger, Martin D. ;

Meisel, Alexander ;

Andres, Martin ;

Schanz, Urs ;

Schwarz, Urs ;

Stussi, Georg .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (09) :E33-E34

[5] Nonmyeloablative allogeneic stem cell transplantation for refractory Hodgkin's lymphoma complicated by interleukin-2 responsive progressive multifocal leukoencephalopathy [J].

Buckanovich, RJ ;

Liu, G ;

Stricker, C ;

Luger, SM ;

Stadtmauer, EA ;

Schuster, SJ ;

Duffy, K ;

Tsai, D ;

Pruitt, A ;

Porter, DL .

ANNALS OF HEMATOLOGY, 2002, 81 (07) :410-413

[6] Progressive Multifocal Leukoencephalopathy Associated With Brentuximab Vedotin Therapy A Report of 5 Cases from the Southern Network on Adverse Reactions (SONAR) Project [J].

Carson, Kenneth R. ;

Newsome, Scott D. ;

Kim, Ellen J. ;

Wagner-Johnston, Nina D. ;

von Geldern, Gloria ;

Moskowitz, Craig H. ;

Moskowitz, Alison J. ;

Rook, Alain H. ;

Jalan, Pankaj ;

Loren, Alison W. ;

Landsburg, Daniel ;

Coyne, Thomas ;

Tsai, Donald ;

Raisch, Dennis W. ;

Norris, LeAann B. ;

Bookstaver, P. Brandon ;

Sartor, Oliver ;

Bennett, Charles L. .

CANCER, 2014, 120 (16) :2464-2471

[7] Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project [J].

Carson, Kenneth R. ;

Evens, Andrew M. ;

Richey, Elizabeth A. ;

Habermann, Thomas M. ;

Focosi, Daniele ;

Seymour, John F. ;

Laubach, Jacob ;

Bawn, Susie D. ;

Gordon, Leo I. ;

Winter, Jane N. ;

Furman, Richard R. ;

Vose, Julie M. ;

Zelenetz, Andrew D. ;

Mamtani, Ronac ;

Raisch, Dennis W. ;

Dorshimer, Gary W. ;

Rosen, Steven T. ;

Muro, Kenji ;

Gottardi-Littell, Numa R. ;

Talley, Robert L. ;

Sartor, Oliver ;

Green, David ;

Major, Eugene O. ;

Bennett, Charles L. .

BLOOD, 2009, 113 (20) :4834-4840

[8] A progressive neurologic disorder with multiple CNS lesions: A neuroimaging clinicopathologic correlation [J].

Chowdhary, Sajeel ;

Chamberlain, Marc .

JOURNAL OF NEUROIMAGING, 2008, 18 (03) :340-344

[9] A study of mefloquine treatment for progressive multifocal leukoencephalopathy: results and exploration of predictors of PML outcomes [J].

Clifford, David B. ;

Nath, Avindra ;

Cinque, Paola ;

Brew, Bruce J. ;

Zivadinov, Robert ;

Gorelik, Leonid ;

Zhao, Zhenming ;

Duda, Petra .

JOURNAL OF NEUROVIROLOGY, 2013, 19 (04) :351-358

[10] Prolonged CD4 T Cell Lymphopenia Increases Morbidity and Mortality after Renal Transplantation [J].

Ducloux, Didier ;

Courivaud, Cecile ;

Bamoulid, Jamal ;

Vivet, Berengere ;

Chabroux, Aline ;

Deschamps, Marina ;

Rebibou, Jean-Michel ;

Ferrand, Christophe ;

Chalopin, Jean-Marc ;

Tiberghien, Pierre ;

Saas, Philippe .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 21 (05) :868-875

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