Nationwide Surveillance Study of Vancomycin-Intermediate Staphylococcus aureus Strains in Korean Hospitals from 2001 to 2006

被引：26

作者：

Chung, Gyungtae ^{[1
]}

Cha, Jeongok ^{[1
]}

Han, Sunyoung ^{[1
]}

Jang, Heesun ^{[1
]}

Lee, Kyeongmin ^{[1
]}

Yoo, Jaeil ^{[1
]}

Yoo, Jeongsik ^{[1
]}

Kim, Hongbin ^{[2
]}

Eun, Soohoon ^{[1
]}

Kim, Bongsu ^{[1
]}

Park, Ok ^{[3
]}

Lee, Yeong Seon ^{[1
]}

机构：

[1] NIH, Div Antimicrobial Resistance, Ctr Infect Dis, Seoul 122701, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea

[3] Korea Ctr Dis Control & Prevent, Infectious Dis Surveillance Team, Seoul 122701, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2010年 / 20卷 / 03期

关键词：

Staphylococcus aureus; surveillance; vancomycin-intermediate; REDUCED SUSCEPTIBILITY; MULTIPLEX PCR; HETEROGENEOUSLY RESISTANT; TOXIN GENES; GLYCOPEPTIDES; EMERGENCE; IDENTIFICATION; MICHIGAN; PATIENT;

D O I：

10.4014/jmb.0906.06018

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We investigated the prevalence and the molecular characteristics of vancomycin-intermediate Staphylococcus aureus (VISA) among methicillin-resistant Staphylococcus aureus (MRSA) strains isolated from clinical samples at tertiary or general hospitals participating in a nationwide surveillance program for VISA and vancomycin-resistant Staphylococcus aureus (VRSA) in Korea during an 8-week period in each year from 2001 to 2006. Of 41,639 MRSAs isolated, 37,856 were screened and 169 grew on brain heart infusion agar supplemented with 4 mu g/ml vancomycin. A vancomycin MIC of 4 mu g/ml was confirmed for 33 VISA isolates of the 169 isolates. Eighteen of the 33 isolates were classified as hetero-VISA (hVISA) by the population analysis profile (PAP) method. All VISA isolates were susceptible to linezolid, tigecycline, and quinupristin dalfopristin. Most VISA isolates (MIC 4 mu g/ml) showed a PFGE C pattern with sec, seg, and sei enterotoxin genes, including ST5-SCCmec type II, or a PFGE A pattern with sea, including ST239-SCCmec type III.

引用

页码：637 / 642

页数：6

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