Value of multilocus genetic risk score for atrial fibrillation in end-stage kidney disease patients in a Polish population

被引：4

作者：

Saracyn, Marek ^{[1
,2
]}

Kisiel, Bartlomiej ^{[3
]}

Bachta, Artur ^{[3
]}

Franaszczyk, Maria ^{[4
]}

Brodowska-Kania, Dorota ^{[1
]}

Zmudzki, Wawrzyniec ^{[1
]}

Szymanski, Konrad ^{[5
]}

Sokalski, Antoni ^{[6
]}

Klatko, Wieslaw ^{[7
]}

Stopinski, Marek ^{[8
]}

Grochowski, Janusz ^{[9
]}

Paplinski, Marek ^{[10
]}

Gozdzik, Zdzislaw ^{[11
]}

Niemczyk, Longin ^{[12
]}

Bober, Barbara ^{[2
]}

Kolodziej, Maciej ^{[2
]}

Tlustochowicz, Witold ^{[3
]}

Kaminski, Grzegorz ^{[2
]}

Ploski, Rafal ^{[5
]}

Niemczyk, Stanislaw ^{[1
]}

机构：

[1] Mil Inst Med, Dept Internal Dis Nephrol & Dialysis, Szaserow 128, PL-04141 Warsaw, Poland

[2] Mil Inst Med, Dept Endocrinol & Isotope Therapy, Szaserow 128, PL-04141 Warsaw, Poland

[3] Mil Inst Med, Dept Internal Dis & Rheumatol, Szaserow 128, PL-04141 Warsaw, Poland

[4] Inst Cardiol, Dept Med Biol, Mol Biol Lab, Alpejska 42, PL-04628 Warsaw, Poland

[5] Med Univ Warsaw, Dept Med Genet, Pawinskiego 3c, PL-02106 Warsaw, Poland

[6] Hosp Radom, Nephrol & Dialysis Unit, Lekarska 4, PL-26610 Radom, Poland

[7] Publ Hosp Ciechanow, Dept Nephrol, Powstancow Wielkopolskich 2, PL-06400 Ciechanow, Poland

[8] West Hosp, Daleka 11, PL-05825 Grodzisk Mazowiecki, Poland

[9] Hosp Makow Mazowiecki, Witosa 2, PL-06200 Makow Mazowiecki, Poland

[10] Hosp Sokolow Podlaski, Ks Bosko 5, PL-08300 Sokolow Podlaski, Poland

[11] Hosp Skierniewice, Rybickiego 1, PL-96100 Skierniewice, Poland

[12] Warsaw Med Univ, Dept Nephrol Dialysis & Internal Dis, Warsaw, Poland

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

FAMILIAL AGGREGATION; COMMON VARIANTS; RARE VARIANTS; LIFETIME RISK; PREVALENCE; ASSOCIATION; POLYMORPHISM; CHANNELS; MARKERS; PERMEABILITY;

D O I：

10.1038/s41598-018-27382-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genetic factors play a key role in the pathogenesis of atrial fibrillation (AF). We would like to establish an association between previously described single-nucleotide polymorphisms (SNPs) and AF in haemodialysed patients with end-stage kidney disease (ESKD HD) as well as to assess the cumulative effect of all genotyped SNPs on AF risk. Sixteen SNPs were genotyped in 113 patients with AF-ESKD-HD and in 157 controls: without AF (NAF) and with ESKD-HD. The distribution of the risk alleles was compared in both groups and between different sub-phenotypes. The multilocus genetic risk score (GRS) was calculated to estimate the cumulative risk conferred by all SNPs. Several loci showed a trend toward an association with permanent AF (perm-AF): CAV1, Cx40 and PITX2. However, GRS was significantly higher in the AF and perm-AF groups, as compared to NAF. Three of the tested variables were independently associated with AF: male sex, history of myocardial infarction (MI) and GRS. The GRS, which combined 13 previously described SNPs, showed a significant and independent association with AF in a Polish population of patients with ESKD-HD and concomitant AF. Further studies on larger groups of patients are needed to confirm the associations.

引用

页数：8

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