Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1

被引：69
作者：
Tobiume, K
Inage, T
Takeda, K
Enomoto, S
Miyazono, K
Ichijo, H
机构：
[1] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,TOSHIMA KU,TOKYO 170,JAPAN
[2] TOKYO MED & DENT UNIV,DEPT ORAL & MAXILLOFACIAL SURG 2,BUNKYO KU,TOKYO 113,JAPAN
[3] NIHON UNIV,SCH DENT,DEPT ANAT,CHIYODA KU,TOKYO 101,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 239卷 / 03期
关键词：
D O I：
10.1006/bbrc.1997.7580
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mouse cDNA for apoptosis signal-regulating kinase 1 (ASK)1 was isolated, The overall amino acid sequence identity between the mouse and the human ASK1 was 91.9 %, A database search revealed that the kinase domain of ASK1 is evolutionally well-conserved over species among nematode, fly, mouse and human, Northan blot analysis identified a 6-kb transcript of ASK1 which is expressed in the various mouse adult tissues including heart, brain, lung, liver and kidney, Immunohistochemical analysis of mouse embryos (17 days post coitum) revealed a localized expression of ASK1 in developing skin, cartilage and bone, suggesting a possible role for ASK1 in tissue development during embryogenesis as well as cytokine-induced apoptosis. (C) 1997 Academic Press.
引用
收藏
页码：905 / 910
页数：6
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