A Cancer-Recognizing Polymeric Photosensitizer Based on the Tumor Extracellular pH Response of Conjugated Polymers for Targeted Cancer Photodynamic Therapy

被引：23
作者：
Jeong, Songhee [1 ]
Park, Wooram [1 ]
Lee, Chung-Sung [1 ]
Na, Kun [1 ]
机构：
[1] Catholic Univ Korea, Dept Biotechnol, Ctr Photomed, Bucheon Si 420743, Gyeonggi Do, South Korea
来源：
MACROMOLECULAR BIOSCIENCE | 2014年 / 14卷 / 12期
基金：
新加坡国家研究基金会;
关键词：
cancer; drug delivery; photodynamic therapy; photosensitizer; pH-responsive polymer; PLURONIC F127; NANOPARTICLES; NANOHYBRIDS; MICELLE; CHARGE; E6;
D O I：
10.1002/mabi.201400361
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Herein, a cancer-recognizing polymeric photosensitizer (CRPP) was demonstrated not only for high water solubility but also for pH-responsive targeted photodynamic cancer therapy. The synthesized CRPP exhibited high water solubility and the pH-dependent charge-switching property. From an in vitro cellular internalization study with HCT-116 human colon cancer cells, significantly enhanced cellular uptake as detected for CRPP at pH 6.5 compared to the cellular uptake of CRPP at pH 7.4, which led to enhanced cytotoxicity in the cancer cells. Finally, the CRPP was found to exhibit high tumor-targeting efficacy in an in vivo tumor model and was finally excreted through the renal route.
引用
收藏
页码：1688 / 1695
页数：8
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  • [1] Photodynamic Therapy of Cancer: An Update
    Agostinis, Patrizia
    Berg, Kristian
    Cengel, Keith A.
    Foster, Thomas H.
    Girotti, Albert W.
    Gollnick, Sandra O.
    Hahn, Stephen M.
    Hamblin, Michael R.
    Juzeniene, Asta
    Kessel, David
    Korbelik, Mladen
    Moan, Johan
    Mroz, Pawel
    Nowis, Dominika
    Piette, Jacques
    Wilson, Brian C.
    Golab, Jakub
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2011, 61 (04) : 250 - 281
  • [2] Oncologic photodynamic therapy photosensitizers: A clinical review
    Allison, Ron R.
    Sibata, Claudio H.
    [J]. PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2010, 7 (02) : 61 - 75
  • [3] Self-quenching polysaccharide-based nanogels of pullulan/folate-photosensitizer conjugates for photodynamic therapy
    Bae, Byoung-chan
    Na, Kun
    [J]. BIOMATERIALS, 2010, 31 (24) : 6325 - 6335
  • [4] Bioreducible Branched Polyethyleneimine Derivatives Physically Loaded with Hydrophobic Pheophorbide A: Preparation, Characterization, and Light-Induced Cytotoxicity
    Cho, Hana
    Li, Li
    Bae, You Han
    Huh, Kang Moo
    Kang, Han Chang
    [J]. MACROMOLECULAR BIOSCIENCE, 2014, 14 (10) : 1483 - 1494
  • [5] Targeted zwitterionic near-infrared fluorophores for improved optical imaging
    Choi, Hak Soo
    Gibbs, Summer L.
    Lee, Jeong Heon
    Kim, Soon Hee
    Ashitate, Yoshitomo
    Liu, Fangbing
    Hyun, Hoon
    Park, GwangLi
    Xie, Yang
    Bae, Soochan
    Henary, Maged
    Frangioni, John V.
    [J]. NATURE BIOTECHNOLOGY, 2013, 31 (02) : 148 - 153
  • [6] Rapid translocation of nanoparticles from the lung airspaces to the body
    Choi, Hak Soo
    Ashitate, Yoshitomo
    Lee, Jeong Heon
    Kim, Soon Hee
    Matsui, Aya
    Insin, Numpon
    Bawendi, Moungi G.
    Semmler-Behnke, Manuela
    Frangioni, John V.
    Tsuda, Akira
    [J]. NATURE BIOTECHNOLOGY, 2010, 28 (12) : 1300 - U113
  • [7] Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation
    Choi, Hak Soo
    Frangioni, John V.
    [J]. MOLECULAR IMAGING, 2010, 9 (06): : 291 - 310
  • [8] THE PREPARATION OF N-CARBOXYANHYDRIDES OF ALPHA-AMINO-ACIDS USING BIS(TRICHLOROMETHYL)CARBONATE
    DALY, WH
    POCHE, D
    [J]. TETRAHEDRON LETTERS, 1988, 29 (46) : 5859 - 5862
  • [9] Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy
    Huang, Peng
    Lin, Jing
    Wang, Xiansong
    Wang, Zhe
    Zhang, Chunlei
    He, Meng
    Wang, Kan
    Chen, Feng
    Li, Zhiming
    Shen, Guangxia
    Cui, Daxiang
    Chen, Xiaoyuan
    [J]. ADVANCED MATERIALS, 2012, 24 (37) : 5104 - 5110
  • [10] Photochemical Properties and Activity of Water-Soluble Polymer/C60 Nanohybrids for Photodynamic Therapy
    Hurtgen, Marie
    Debuigne, Antoine
    Hoebeke, Maryse
    Passirani, Catherine
    Lautram, Nolwenn
    Mouithys-Mickalad, Ange
    Guelluy, Pierre-Henri
    Jerome, Christine
    Detrembleur, Christophe
    [J]. MACROMOLECULAR BIOSCIENCE, 2013, 13 (01) : 106 - 115
123