A Cancer-Recognizing Polymeric Photosensitizer Based on the Tumor Extracellular pH Response of Conjugated Polymers for Targeted Cancer Photodynamic Therapy

被引：25

作者：

Jeong, Songhee ^{[1
]}

Park, Wooram ^{[1
]}

Lee, Chung-Sung ^{[1
]}

Na, Kun ^{[1
]}

机构：

[1] Catholic Univ Korea, Dept Biotechnol, Ctr Photomed, Bucheon Si 420743, Gyeonggi Do, South Korea

来源：

MACROMOLECULAR BIOSCIENCE | 2014年 / 14卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

cancer; drug delivery; photodynamic therapy; photosensitizer; pH-responsive polymer; PLURONIC F127; NANOPARTICLES; NANOHYBRIDS; MICELLE; CHARGE; E6;

D O I：

10.1002/mabi.201400361

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Herein, a cancer-recognizing polymeric photosensitizer (CRPP) was demonstrated not only for high water solubility but also for pH-responsive targeted photodynamic cancer therapy. The synthesized CRPP exhibited high water solubility and the pH-dependent charge-switching property. From an in vitro cellular internalization study with HCT-116 human colon cancer cells, significantly enhanced cellular uptake as detected for CRPP at pH 6.5 compared to the cellular uptake of CRPP at pH 7.4, which led to enhanced cytotoxicity in the cancer cells. Finally, the CRPP was found to exhibit high tumor-targeting efficacy in an in vivo tumor model and was finally excreted through the renal route.

引用

收藏

页码：1688 / 1695

页数：8

相关论文

共 26 条

[1] Photodynamic Therapy of Cancer: An Update [J].

Agostinis, Patrizia ;

Berg, Kristian ;

Cengel, Keith A. ;

Foster, Thomas H. ;

Girotti, Albert W. ;

Gollnick, Sandra O. ;

Hahn, Stephen M. ;

Hamblin, Michael R. ;

Juzeniene, Asta ;

Kessel, David ;

Korbelik, Mladen ;

Moan, Johan ;

Mroz, Pawel ;

Nowis, Dominika ;

Piette, Jacques ;

Wilson, Brian C. ;

Golab, Jakub .

CA-A CANCER JOURNAL FOR CLINICIANS, 2011, 61 (04) :250-281

[2] Oncologic photodynamic therapy photosensitizers: A clinical review [J].

Allison, Ron R. ;

Sibata, Claudio H. .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2010, 7 (02) :61-75

[3] Self-quenching polysaccharide-based nanogels of pullulan/folate-photosensitizer conjugates for photodynamic therapy [J].

Bae, Byoung-chan ;

Na, Kun .

BIOMATERIALS, 2010, 31 (24) :6325-6335

[4] Bioreducible Branched Polyethyleneimine Derivatives Physically Loaded with Hydrophobic Pheophorbide A: Preparation, Characterization, and Light-Induced Cytotoxicity [J].

Cho, Hana ;

Li, Li ;

Bae, You Han ;

Huh, Kang Moo ;

Kang, Han Chang .

MACROMOLECULAR BIOSCIENCE, 2014, 14 (10) :1483-1494

[5] Targeted zwitterionic near-infrared fluorophores for improved optical imaging [J].

Choi, Hak Soo ;

Gibbs, Summer L. ;

Lee, Jeong Heon ;

Kim, Soon Hee ;

Ashitate, Yoshitomo ;

Liu, Fangbing ;

Hyun, Hoon ;

Park, GwangLi ;

Xie, Yang ;

Bae, Soochan ;

Henary, Maged ;

Frangioni, John V. .

NATURE BIOTECHNOLOGY, 2013, 31 (02) :148-153

[6] Rapid translocation of nanoparticles from the lung airspaces to the body [J].

Choi, Hak Soo ;

Ashitate, Yoshitomo ;

Lee, Jeong Heon ;

Kim, Soon Hee ;

Matsui, Aya ;

Insin, Numpon ;

Bawendi, Moungi G. ;

Semmler-Behnke, Manuela ;

Frangioni, John V. ;

Tsuda, Akira .

NATURE BIOTECHNOLOGY, 2010, 28 (12) :1300-U113

[7] Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation [J].

Choi, Hak Soo ;

Frangioni, John V. .

MOLECULAR IMAGING, 2010, 9 (06) :291-310

[8] THE PREPARATION OF N-CARBOXYANHYDRIDES OF ALPHA-AMINO-ACIDS USING BIS(TRICHLOROMETHYL)CARBONATE [J].

DALY, WH ;

POCHE, D .

TETRAHEDRON LETTERS, 1988, 29 (46) :5859-5862

[9] Light-Triggered Theranostics Based on Photosensitizer-Conjugated Carbon Dots for Simultaneous Enhanced-Fluorescence Imaging and Photodynamic Therapy [J].

Huang, Peng ;

Lin, Jing ;

Wang, Xiansong ;

Wang, Zhe ;

Zhang, Chunlei ;

He, Meng ;

Wang, Kan ;

Chen, Feng ;

Li, Zhiming ;

Shen, Guangxia ;

Cui, Daxiang ;

Chen, Xiaoyuan .

ADVANCED MATERIALS, 2012, 24 (37) :5104-5110

[10] Photochemical Properties and Activity of Water-Soluble Polymer/C60 Nanohybrids for Photodynamic Therapy [J].

Hurtgen, Marie ;

Debuigne, Antoine ;

Hoebeke, Maryse ;

Passirani, Catherine ;

Lautram, Nolwenn ;

Mouithys-Mickalad, Ange ;

Guelluy, Pierre-Henri ;

Jerome, Christine ;

Detrembleur, Christophe .

MACROMOLECULAR BIOSCIENCE, 2013, 13 (01) :106-115