Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease

被引：39
作者：
Brindle, N
Song, Y
Rogaeva, E
Premkumar, S
Levesque, G
Yu, G
Ikeda, M
Nishimura, M
Paterson, A
Sorbi, S
Duara, R
Farrer, L
St George-Hyslop, P
机构：
[1] Univ Toronto, Dept Med, Div Neurol, Ctr Res Neurodegenerat Dis, Toronto, ON M5S 3H2, Canada
[2] Toronto Hosp, Dept Med, Div Neurol, Toronto, ON M5S 3H2, Canada
[3] Boston Univ, Sch Med, Dept Neurol, Neurogenet Lab, Boston, MA 02118 USA
[4] Univ Toronto, Clarke Inst Psychiat, Neurogenet Lab, Toronto, ON, Canada
[5] Dept Neurol & Psychiat, I-50134 Florence, Italy
[6] Mt Sinai Med Ctr, Wein Ctr, Dept Neurol, Miami Beach, FL 33140 USA
来源：
HUMAN MOLECULAR GENETICS | 1998年 / 7卷 / 05期
关键词：
D O I：
10.1093/hmg/7.5.933
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the epsilon 4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.
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页码：933 / 935
页数：3
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