Complete Sequences of mcr-1-Harboring Plasmids from Extended-Spectrum-β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae

被引：121

作者：

Li, Aiqing ^{[1
]}

Yang, Yong ^{[1
]}

Miao, Minhui ^{[1
]}

Chavda, Kalyan D. ^{[2
]}

Mediavilla, Jose R. ^{[2
]}

Xie, Xiaofang ^{[1
]}

Feng, Ping ^{[1
]}

Tang, Yi-Wei ^{[3
]}

Kreiswirth, Barry N. ^{[2
]}

Chen, Liang ^{[2
]}

Du, Hong ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 2, Dept Clin Lab, Suzhou, Jiangsu, Peoples R China

[2] Rutgers State Univ, New Jersey Med Sch, Publ Hlth Res Inst, TB Ctr, Newark, NJ 07102 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Lab Med, 1275 York Ave, New York, NY 10021 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 07期

基金：

中国国家自然科学基金;

关键词：

COLISTIN RESISTANCE GENE; ESCHERICHIA-COLI; MCR-1; DISSEMINATION; INFECTION;

D O I：

10.1128/AAC.00550-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here we completely sequenced four mcr-1-haboring plasmids, isolated from two extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1-harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST25 isolates were identical (all pMCR1-IncX4), belonging to the IncX4 incompatibility group, while the plasmid from an E. coli ST2085 isolate (pMCR1-IncI2) belongs to the IncI2 group. A nearly identical 2.6-kb mcr-1-pap2 element was found to be shared by all mcr-1-carrying plasmids.

引用

页码：4351 / 4354

页数：4

共 28 条

[1] SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing [J].

Bankevich, Anton ;

Nurk, Sergey ;

Antipov, Dmitry ;

Gurevich, Alexey A. ;

Dvorkin, Mikhail ;

Kulikov, Alexander S. ;

Lesin, Valery M. ;

Nikolenko, Sergey I. ;

Son Pham ;

Prjibelski, Andrey D. ;

Pyshkin, Alexey V. ;

Sirotkin, Alexander V. ;

Vyahhi, Nikolay ;

Tesler, Glenn ;

Alekseyev, Max A. ;

Pevzner, Pavel A. .

JOURNAL OF COMPUTATIONAL BIOLOGY, 2012, 19 (05) :455-477

[2] Infection by and dissemination of NDM-5-producing Escherichia coli in China [J].

Chen, Dongke ;

Gong, Lin ;

Walsh, Timothy R. ;

Lan, Ruiting ;

Wang, Tuo ;

Zhang, Jidong ;

Mai, Wenhui ;

Ni, Na ;

Lu, Jinxing ;

Xu, Jianguo ;

Li, Juan .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016, 71 (02) :563-565

[3] Molecular Characterization by Using Next-Generation Sequencing of Plasmids Containing blaNDM-7 in Enterobacteriaceae from Calgary, Canada [J].

Chen, L. ;

Peirano, G. ;

Lynch, T. ;

Chavda, K. D. ;

Gregson, D. B. ;

Church, D. L. ;

Conly, J. ;

Kreiswirth, B. N. ;

Pitout, J. D. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (03) :1258-1263

[4] Complete Sequence of a KPC-Producing IncN Multidrug-Resistant Plasmid from an Epidemic Escherichia coli Sequence Type 131 Strain in China [J].

Chen, Liang ;

Hu, Hongyan ;

Chavda, Kalyan D. ;

Zhao, Shulong ;

Liu, Renkun ;

Liang, Hui ;

Zhang, Wei ;

Wang, Xiumei ;

Jacobs, Michael R. ;

Bonomo, Robert A. ;

Kreiswirth, Barry N. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (04) :2422-2425

[5] Complete Nucleotide Sequence of a blaKPC-Harboring IncI2 Plasmid and Its Dissemination in New Jersey and New York Hospitals [J].

Chen, Liang ;

Chavda, Kalyan D. ;

Al Laham, Nahed ;

Melano, Roberto G. ;

Jacobs, Michael R. ;

Bonomo, Robert A. ;

Kreiswirth, Barry N. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (10) :5019-5025

[6] Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates [J].

Diancourt, L ;

Passet, V ;

Verhoef, J ;

Grimont, PAD ;

Brisse, S .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (08) :4178-4182

[7] Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae [J].

Du, Hong ;

Chen, Liang ;

Tang, Yi-Wei ;

Kreiswirth, Barry N. .

LANCET INFECTIOUS DISEASES, 2016, 16 (03) :287-288

[8] The use of whole-genome sequencing for molecular epidemiology and antimicrobial surveillance: identifying the role of IncX3 plasmids and the spread of blaNDM-4-like genes in the Enterobacteriaceae [J].

Espedido, Bjoern A. ;

Dimitrijovski, Borce ;

van Hal, Sebastiaan J. ;

Jensen, Slade O. .

JOURNAL OF CLINICAL PATHOLOGY, 2015, 68 (10) :835-838

[9] Colistin resistance gene mcr-1 in extended-spectrum β-lactamase-producing and carbapenemase-producing Gram-negative bacteria in Germany [J].

Falgenhauer, Linda ;

Waersada, Said-Elias ;

Yao, Yancheng ;

Imirzalioglu, Can ;

Kaesbohrer, Annemarie ;

Roesler, Uwe ;

Michael, Geovana Brenner ;

Schwarz, Stefan ;

Werner, Guido ;

Kreienbrock, Lothar ;

Chakraborty, Trinad .

LANCET INFECTIOUS DISEASES, 2016, 16 (03) :282-283

[10] Co-occurrence of extended spectrum β lactamase and MCR-1 encoding genes on plasmids [J].

Haenni, Marisa ;

Poirel, Laurent ;

Kieffer, Nicolas ;

Chatre, Pierre ;

Saras, Estelle ;

Metayer, Veronique ;

Dumoulin, Romain ;

Nordmann, Patrice ;

Madec, Jean-Yves .

LANCET INFECTIOUS DISEASES, 2016, 16 (03) :281-282

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