Synthesis, Crystal Structure and Antitumor Activities of N-(2-(2-hydroxy-2-phenylacetyl)phenyl)cinnamamide

The title compound N-(2-(2-hydroxy-2-phenylacetyl)phenyl)cinnamamide (C23H19NO3, M-r = 357.39) has been synthesized with 2-iodoaniline and ethynylbenzene as starting materials, and its crystal structure was determined by H-1 NMR, C-13 NMR, H RMS and single-crystal X-ray diffraction for the first time. The crystal crystallizes in monoclinic system, space group P2(1)/c with a = 8.2850(7), b = 25.934(2), c = 8.3032(6) angstrom, beta = 95.314(7)degrees, V = 1776.4(3) angstrom(3), Z = 4, T = 293(2) K, mu(CuK alpha) = 0.71 mm(-1), D-c = 1.336 Mg/cm(3), 3019 reflections measured (6.832 <= 2 theta <= 129.982 degrees), 2996 unique (R-int = 0.0463, R-sigma = 0.0549) which were used in all calculations. The final R= 0.0880 (I > 2 sigma (I)) and wR = 0.2447 (all data). The target compound has demonstrated weak or moderate anti-tumor activity against human leukemia k562cell, human promyelocytic leukemia HL-60 cell, human gastric cancer line BGC-823, Hela cell and lung cancer A549 cell.