Molecular aspects of membrane fission in the secretory pathway

被引:50
作者
Corda, D [1 ]
Carcedo, CH [1 ]
Bonazzi, M [1 ]
Luini, A [1 ]
Spanò, S [1 ]
机构
[1] Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, Dept Cell Biol & Oncol, I-66030 Santa Maria Imbaro, Italy
关键词
CtBP3/BARS; Golgi complex; membrane traffic; acyl-transferase; acyl-CoA; phosphatidic acid; phospholipase D; protein kinase; PITP;
D O I
10.1007/PL00012508
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Membrane fission is essential in various intracellular dissociative transport steps. The molecular mechanisms by which endocytic vesicles detach from the plasma membrane are being rapidly elucidated. Much less is known about the fission mechanisms operating at Golgi tubular networks; these include the Golgi transport and sorting stations, the trans-Golgi and cis-Golgi networks, where the geometry and physical properties of the membranes differ from those at the cell surface. Here we discuss the lipid and protein machineries that have so far been related to the fission process, with emphasis on those acting in the Golgi complex.
引用
收藏
页码:1819 / 1832
页数:14
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