Potential role for metformin in urologic oncology

被引：9

作者：

Sayyid, Rashid Khalid ^{[1
]}

Fleshner, Neil Eric ^{[1
]}

机构：

[1] Princess Margaret Canc Ctr, Dept Urol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada

来源：

INVESTIGATIVE AND CLINICAL UROLOGY | 2016年 / 57卷 / 03期

关键词：

Kidney neoplasms; Metformin; Prostatic neoplasms; Urinary bladder neoplasms; PROSTATE-CANCER CELLS; ANDROGEN-DEPRIVATION THERAPY; BLADDER-CANCER; DOWN-REGULATION; IN-VITRO; DIABETES-MELLITUS; RISK; MEN; ASSOCIATION; MORTALITY;

D O I：

10.4111/icu.2016.57.3.157

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Metformin is one of the most commonly used drugs worldwide. It is currently considered first-line pharmacological agent for management of diabetes mellitus type 2. Recent studies have suggested that metformin may have further benefits, especially in the field of urologic oncology. Use of metformin has been shown to be associated with decreased incidence and improved outcomes of prostate, bladder, and kidney cancer. These studies suggest that metformin does have a future role in the prevention and management of urologic malignancies. In this review, we will discuss the latest findings in this field and its implications on the management of urologic oncology patients.

引用

页码：157 / 164

页数：8

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