The pH-dependent, ATP-independent interaction of collagen specific serpin stress protein HSP47

被引：0
作者：
ElThaher, TSH
Drake, AF
Yokota, S
Nakai, A
Nagata, K
Miller, AD
机构：
[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL, DEPT CHEM, LONDON SW7 2AY, ENGLAND
[2] UNIV LONDON BIRKBECK COLL, DEPT CHEM, EPSRC, NATL CHIROPT SPECT CTR, LONDON WC1H 0AJ, ENGLAND
[3] KYOTO UNIV, CHEST DIS RES INST, DEPT CELL BIOL, KYOTO 606, JAPAN
来源：
PROTEIN AND PEPTIDE LETTERS | 1996年 / 3卷 / 01期
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D O I：
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中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heat Shock Protein 47 (HSP47) is a procollagen/collagen specific stress protein which belongs to the Serpin superfamily and which binds to procollagen/collagen in an unusual pH-dependent, ATP-independent manner. Here we show, by means of circular dichroism and fluorescence spectroscopy, that HSP47 undergoes reversible pH-induced conformational changes which could account for the pH-dependent binding behaviour.(1)
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页码：1 / 8
页数：8
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