Poly(ethylene glycol)-polypeptide Copolymer Micelles for Therapeutic Agent Delivery

被引：8
|
作者：
Cheng, Yilong [1 ,2 ]
机构：
[1] Univ Washington, Dept Bioengn, 3720 15th Ave NE,Box 355061, Seattle, WA 98195 USA
[2] Univ Washington, Mol Engn & Sci Inst, 3720 15th Ave NE,Box 355061, Seattle, WA 98195 USA
来源：
CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2016年 / 17卷 / 03期
关键词：
Polypeptide; poly(ethylene glycol); amphiphilic; micelles; therapeutic agents; ENHANCED CHEMOTHERAPY EFFICACY; RING-OPENING POLYMERIZATION; POLY-L-LYSINE; DRUG-DELIVERY; POLYPEPTIDE NANOGELS; N-CARBOXYANHYDRIDE; GENE DELIVERY; THERMOSENSITIVE HYDROGELS; HYBRID POLYPEPTIDES; ANTITUMOR EFFICACY;
D O I：
10.2174/1389201017666151223124135
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Poly(ethylene glycol)-polypeptide (PEG-polypeptide) based polymeric micelles as therapeutic agent carriers have received considerable interest due to their advanced achievements in clinical trials. Polypeptides not only show well-defined secondary structure (alfa-helix and beta-sheet) and good biocompatibility, but can also be functionalized with various groups by direct N-carboxyanhydrides (NCAs) polymerization or further modification. Additionally, the ionizable side chains enable them to deliver diverse therapeutic agents, such as negative nucleic acid and positive doxorubicin. In this review, we firstly summarized the synthetic methods of amphiphilic copolymers PEG-polypeptide, and emphatically discussed recent progress on their applications as nanocarriers for therapeutic agents from following aspects: PEG-nonionic polypeptide copolymer micelles, PEG-anionic polypeptide micelles, and PEG-cationic polypeptide micelles.
引用
收藏
页码：212 / 226
页数：15
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