Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved

被引：11

作者：

Afelik, Solomon ^{[1
]}

Rovira, Meritxell ^{[2
]}

机构：

[1] Univ Illinois, Dept Surg, Div Transplantat, 840 South Wood St,CSB 920,Rm 502, Chicago, IL 60612 USA

[2] Ctr Regenerat Med Barcelona CMRB, Dr Aiguader 88, Barcelona 08003, Spain

来源：

GENOME MEDICINE | 2017年 / 9卷

关键词：

DIFFERENTIATION; MICE;

D O I：

10.1186/s13073-017-0437-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent advances in β-cell regeneration in vivo are providing insights into the mechanisms involved in the conversion of distinct pancreatic cell lineages into β cells. These mechanisms mostly involve reactivation of the gene encoding the pancreatic endocrine cell-specifying transcription factor neurogenin-3.

引用

页数：4

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