Dynamic kinetic resolution of primary amines with a recyclable Pd nanocatalyst for racemization

被引：146

作者：

Kim, Mahn-Joo ^{[1
]}

Kim, Won-Hee ^{[1
]}

Han, Kiwon ^{[1
]}

Choi, Yoon Kyung ^{[1
]}

Park, Jaiwook ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, South Korea

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 06期

关键词：

D O I：

10.1021/ol070130d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical procedure for the dynamic kinetic resolution (DKR) of primary amines has been developed. This procedure employs a palladium nanocatalyst as the racemization catalyst, a commercial lipase (Novozym-435) as the resolution catalyst, and ethyl acetate or ethyl methoxyacetate as the acyl donor. Eleven primary amines and one amino acid amide have been efficiently resolved with good yields (85-99%) and high enantiomeric excesses (97-99%).

引用

页码：1157 / 1159

页数：3

共 22 条

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[2]

2-P

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