Olfactory and gustatory functioning and food preferences of patients with Alzheimer's disease and mild cognitive impairment compared to controls: the NUDAD project

被引：30

作者：

Doorduijn, A. S. ^{[1
,2
]}

de van der Schueren, M. A. E. ^{[1
,3
]}

van de Rest, O. ^{[4
]}

de Leeuw, F. A. ^{[2
,5
]}

Fieldhouse, J. L. P. ^{[2
]}

Kester, M. I. ^{[2
]}

Teunissen, C. E. ^{[5
]}

Scheltens, P. ^{[2
]}

van der Flier, W. M. ^{[2
]}

Visser, M. ^{[6
,7
]}

Boesveldt, S. ^{[4
]}

机构：

[1] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Amsterdam UMC, Dept Nutr & Dietet, POB 7057, NL-1007 MB Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands

[3] HAN Univ Appl Sci, Dept Nutr & Hlth, Nijmegen, Netherlands

[4] Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands

[5] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Neurochem Lab,Dept Clin Chem, Amsterdam, Netherlands

[6] Vrije Univ Amsterdam, Fac Sci, Dept Hlth Sci, Amsterdam, Netherlands

[7] Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands

来源：

JOURNAL OF NEUROLOGY | 2020年 / 267卷 / 01期

关键词：

Older adults; Malnutrition; Dementia; Cognition; ODOR IDENTIFICATION; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DEMENTIA; TASTE; DISCRIMINATION; RECOMMENDATIONS; MACRONUTRIENT; PREVALENCE;

D O I：

10.1007/s00415-019-09561-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Our aim is to compare olfactory and gustatory function and food preferences of patients with Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) with controls. We included 22 patients with MCI, 30 patients with AD and 40 controls and assessed olfactory threshold, odor discrimination and odor identification (Sniffin' Sticks), gustatory functioning (Taste Strips), and food preferences (Macronutrient and Taste Preference Ranking Task). Linear regression analyses were used to study associations of five cognitive domains or AD biomarkers with olfactory functioning. Groups did not differ in olfactory threshold, gustatory function and food preferences. Patients with MCI and AD scored lower on odor discrimination and identification than controls. Poorer memory, but no other cognitive domain, was associated with poorer odor discrimination and odor identification, but not with odor threshold. No associations with AD biomarkers were found. In conclusion, patients with MCI and AD have poorer odor discrimination and identification ability than controls, but similar detection thresholds. This is likely a consequence of poorer memory rather than directly caused by AD pathology.

引用

页码：144 / 152

页数：9

共 52 条

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