Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles

被引:198
作者
Anand, Sushma [1 ]
Samuel, Monisha [1 ]
Kumar, Sharad [2 ,3 ]
Mathivanan, Suresh [1 ]
机构
[1] La Trobe Univ, La Trobe Inst Mol Sci, Dept Biochem & Genet, Bundoora, Vic 3086, Australia
[2] Univ South Australia, Ctr Canc Biol, GPO Box 2471, Adelaide, SA 5001, Australia
[3] SA Pathol, GPO Box 2471, Adelaide, SA 5001, Australia
来源
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2019年 / 1867卷 / 12期
基金
澳大利亚研究理事会; 英国医学研究理事会;
关键词
Extracellular vesicles; Cargo sorting; Post translational modifications; Ubiquitination; CELL-DERIVED EXOSOMES; FAS LIGAND; SECRETION; PROTEIN; BIOGENESIS; MICROVESICLES; MECHANISMS; UBIQUITIN; RELEASE; TSG101;
D O I
10.1016/j.bbapap.2019.02.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Extracellular vesicles (EVs) are released by cells into the extracellular milieu to facilitate intercellular communication in both physiological and pathological condition. EVs contain selective repertoires of proteins, RNAs, lipids and metabolites that moderate signalling pathways in the recipient cells. The enrichment of a particular set of proteins or RNAs within the EVs highlights the existence of specific sorting mechanisms that orchestrate the selective packaging of the cargo. The molecular machinery of cargo sorting has remained obscure over the years and functional studies are required to understand this complex mechanism. In this article, we offer a brief overview of the molecular mechanisms that are known to regulate sorting of various molecules into EVs. We also discuss how different pathways of biogenesis alter the exosomal cargo as well and the implications of the cellular state on the content of the EVs. Understanding the sorting of exosomal cargo could further be exploited in clinical settings for targeted drug delivery and to block disease progression.
引用
收藏
页数:10
相关论文
共 128 条
[1]   Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies [J].
Akers, Johnny C. ;
Gonda, David ;
Kim, Ryan ;
Carter, Bob S. ;
Chen, Clark C. .
JOURNAL OF NEURO-ONCOLOGY, 2013, 113 (01) :1-11
[2]   Arrestin-Domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles [J].
Anand, Sushma ;
Foot, Natalie ;
Ang, Ching-Seng ;
Gembus, Kelly M. ;
Keerthikumar, Shivakumar ;
Adda, Christopher G. ;
Mathivanan, Suresh ;
Kumar, Sharad .
PROTEOMICS, 2018, 18 (17)
[3]   Tetraspanins in extracellular vesicle formation and function [J].
Andreu, Zoraida ;
Yanez-Mo, Maria .
FRONTIERS IN IMMUNOLOGY, 2014, 5
[4]   A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure [J].
Atkin-Smith, Georgia K. ;
Tixeira, Rochelle ;
Paone, Stephanie ;
Mathivanan, Suresh ;
Collins, Christine ;
Liem, Michael ;
Goodall, Katharine J. ;
Ravichandran, Kodi S. ;
Hulett, Mark D. ;
Poon, Ivan K. H. .
NATURE COMMUNICATIONS, 2015, 6
[5]   Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species [J].
Baglio, Serena Rubina ;
Rooijers, Koos ;
Koppers-Lalic, Danijela ;
Verweij, Frederik J. ;
Lanzon, M. Perez ;
Zini, Nicoletta ;
Naaijkens, Benno ;
Perut, Francesca ;
Niessen, Hans W. M. ;
Baldini, Nicola ;
Pegtel, D. Michiel .
STEM CELL RESEARCH & THERAPY, 2015, 6
[6]   Syndecan-syntenin-ALIX regulates the biogenesis of exosomes [J].
Baietti, Maria Francesca ;
Zhang, Zhe ;
Mortier, Eva ;
Melchior, Aurelie ;
Degeest, Gisele ;
Geeraerts, Annelies ;
Ivarsson, Ylva ;
Depoortere, Fabienne ;
Coomans, Christien ;
Vermeiren, Elke ;
Zimmermann, Pascale ;
David, Guido .
NATURE CELL BIOLOGY, 2012, 14 (07) :677-685
[7]   Identification of a Conserved Glycan Signature for Microvesicles [J].
Batista, Bianca S. ;
Eng, William S. ;
Pilobello, Kanoelani T. ;
Hendricks-Munoz, Karen D. ;
Mahal, Lara K. .
JOURNAL OF PROTEOME RESEARCH, 2011, 10 (10) :4624-4633
[8]   Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding [J].
Blot, V ;
Perugi, F ;
Gay, B ;
Prévost, MC ;
Briant, L ;
Tangy, F ;
Abriel, H ;
Staub, O ;
Dokhélar, MC ;
Pique, C .
JOURNAL OF CELL SCIENCE, 2004, 117 (11) :2357-2367
[9]   NEDD4: The founding member of a family of ubiquitin-protein ligases [J].
Boase, Natasha Anne ;
Kumar, Sharad .
GENE, 2015, 557 (02) :113-122
[10]   Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation [J].
Bobrie, Angelique ;
Colombo, Marina ;
Krumeich, Sophie ;
Raposo, Graca ;
Thery, Clotilde .
JOURNAL OF EXTRACELLULAR VESICLES, 2012, 1 (01)