The role of dopamine in the mechanism of action of antidepressant drugs

被引：243
作者：
D'Aquila, PS
Collu, M
Cessa, GL
Serra, G
机构：
[1] Univ Sassari, Dipartimento Sci Farmaco, I-07100 Sassari, Italy
[2] Univ Cagliari, Bb Brodie Dept Neurosci, I-09124 Cagliari, Italy
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 405卷 / 1-3期
关键词：
antidepressant drug; dopamine; depression; mania; mesolimbic dopamine system;
D O I：
10.1016/S0014-2999(00)00566-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present paper reviews evidence on the effect of antidepressant treatments on dopamine transmission. Chronic treatment with antidepressant drugs potentiates the behavioural stimulant responses elicited by the stimulation of dopamine receptors, including reward-related behaviours. Moreover, antidepressants affect dopamine release in several brain areas. The reviewed literature is discussed in terms of the possible mechanisms underlying antidepressant-induced supersensitivity to dopamine-mediated behavioural responses, and of the possible implications for the therapeutic effect of these drugs. It is concluded that the potentiation of dopaminergic neurotransmission induced by chronic antidepressant treatments might contribute to their therapeutic effect. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：365 / 373
页数：9
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