Acid/base properties of β-blockers and benzodiazepines in sodium dodecyl sulfate micelles.: A spectrophotometric and potentiometric study

被引：10
|
作者：
de Castro, B
Gameiro, P
Guimaraes, C
Lima, JLFC
Reis, S [1 ]
机构：
[1] Univ Porto, Fac Farm, Dept Quim Fis, CEQUP, P-4050 Porto, Portugal
[2] Univ Porto, Fac Ciencias, Dept Quim, CEQUP, P-4050 Porto, Portugal
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1998年 / 87卷 / 03期
关键词：
D O I：
10.1021/js970219k
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The effect of sodium dodecyl sulfate (SDS) micelles on the acid-base properties of two family of pharmaceutical drugs (beta-blockers and benzodiazepines) at 25 degrees C and I = 0.1 M NaCl have been studied. The characterization of the several solution equilibria for the system drug/SDS micelle solution was performed by potentiometry and spectrophotometry, below and above the critical micelle concentration (cmc). Two widely used models have been applied to quantify the effect of micelles on the pK(a) of the drugs, and the results obtained point to different interactions of each family of drugs with the micelles.
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页码：356 / 359
页数：4
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