Evolution of transcription factor function

被引:71
|
作者
Hsia, CC [1 ]
McGinnis, W [1 ]
机构
[1] Univ Calif San Diego, Sect Cell & Dev Biol, La Jolla, CA 92093 USA
关键词
D O I
10.1016/S0959-437X(03)00017-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Functional assays in Drosophila melanogaster with orthologous transcription factors from other species suggest that changes in the protein-coding sequence may play a larger role in the evolution of transcription factor pathways than was previously believed. Interestingly, recent studies provide evidence that changes in transcription factor protein sequence can affect the regulation of only a subset of target genes, even in the same cells of a developing animal.
引用
收藏
页码:199 / 206
页数:8
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