The application of sulfur-containing peptides in drug discovery

被引:76
作者
Zhao, Jiaoyan [1 ]
Jiang, Xuefeng [1 ,2 ]
机构
[1] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China
[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
基金
中国国家自然科学基金;
关键词
Peptides; Disulfide; Thioether; Thiazole; Drug discovery; RECEPTOR AGONIST LIXISENATIDE; CALCIUM-SENSING RECEPTOR; PLACEBO-CONTROLLED TRIAL; HEART-FAILURE; DOUBLE-BLIND; SECONDARY HYPERPARATHYROIDISM; THERAPEUTIC PEPTIDES; NATRIURETIC PEPTIDE; PARATHYROID-HORMONE; BASAL INSULIN;
D O I
10.1016/j.cclet.2018.05.026
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
recent decades, peptides as potential drugs were more and more explored with the development of non-oral medicine. There into, sulfur-containing peptide is one of the most popular aspects in peptide drugs due to the introduction of sulfur atoms leading unique properties. The purpose of the present review is to focus on the discovery of various sulfur-containing peptides with particular emphasis on their pharmacological mechanisms. This review is organized according to the structures of the sulfur containing peptides. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:1079 / 1087
页数:9
相关论文
共 91 条
  • [1] Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action
    Alexander, Shawn T.
    Hunter, Thomas
    Walter, Sarah
    Dong, Jin
    Maclean, Derek
    Baruch, Amos
    Subramanian, Raju
    Tomlinson, James E.
    [J]. MOLECULAR PHARMACOLOGY, 2015, 88 (05) : 853 - 865
  • [2] [Anonymous], 2008, DRUG DES DEV THER, DOI DOI 10.2147/DDDT.S3225
  • [3] [Anonymous], 2009, DRUG DISCOV TODAY
  • [4] A pharmacokinetic and pharmacodynamic comparison of desmopressin administered as whole, chewed and crushed tablets, and as an oral solution
    Argenti, D
    Ireland, D
    Heald, DL
    [J]. JOURNAL OF UROLOGY, 2001, 165 (05) : 1446 - 1451
  • [5] Thiopeptide antibiotics
    Bagley, MC
    Dale, JW
    Merritt, EA
    Xiong, A
    [J]. CHEMICAL REVIEWS, 2005, 105 (02) : 685 - 714
  • [6] Bettencourt P, 2002, CARDIOVASC DRUG REV, V20, P27
  • [7] BOGGS SS, 1974, CANCER RES, V34, P1938
  • [8] Icatibant
    Bork, Konrad
    Yasothan, Uma
    Kirkpatrick, Peter
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (10) : 801 - 802
  • [9] Oral Oxytocin Antagonists
    Borthwick, Alan D.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (18) : 6525 - 6538
  • [10] Boucher Marc, 2004, J Obstet Gynaecol Can, V26, P481