Transporting experimental results with entropy balancing

被引:30
作者
Josey, Kevin P. [1 ]
Berkowitz, Seth A. [2 ]
Ghosh, Debashis [1 ]
Raghavan, Sridharan [3 ,4 ]
机构
[1] Univ Colorado, Colorado Sch Publ Hlth, Dept Biostat & Informat, Anschutz Med Campus, Aurora, CO USA
[2] Univ N Carolina, Sch Med, Div Gen Med & Clin Epidemiol, Chapel Hill, NC 27515 USA
[3] Rocky Mt Reg VA Med Ctr, 1700 N Wheeling St, Aurora, CO 80045 USA
[4] Univ Colorado, Sch Med, Div Hosp Med, Aurora, CO USA
基金
美国国家科学基金会;
关键词
calibration; causal inference; effect modification; generalizability; ADJUSTED INDIRECT COMPARISONS; ROBUST ESTIMATION; PROPENSITY SCORE; CAUSAL INFERENCE; MORTALITY; TRANSPORTABILITY; CALIBRATION; ADULTS; HEALTH; TRIAL;
D O I
10.1002/sim.9031
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We show how entropy balancing can be used for transporting experimental treatment effects from a trial population onto a target population. This method is doubly robust in the sense that if either the outcome model or the probability of trial participation is correctly specified, then the estimate of the target population average treatment effect is consistent. Furthermore, we only require the sample moments of the effect modifiers drawn from the target population to consistently estimate the target population average treatment effect. We compared the finite-sample performance of entropy balancing with several alternative methods for transporting treatment effects between populations. Entropy balancing techniques are efficient and robust to violations of model misspecification. We also examine the results of our proposed method in an applied analysis of the Action to Control Cardiovascular Risk in Diabetes Blood Pressure trial transported to a sample of US adults with diabetes taken from the National Health and Nutrition Examination Survey cohort.
引用
收藏
页码:4310 / 4326
页数:17
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