miR-10b represses the proliferation and invasion of prostate cancer by targeting LRH1

Liver receptor homolog 1 (LRH1) plays an important role in the onset and progression of many cancer types. However, the role of LRH1 in prostate cancer has not been well investigated. In this study, the critical role of LRH1 in prostate cancer cells was described. Quantitative polymerase chain reaction and Western blot analysis results revealed that LRH1 was highly overexpressed in prostate cancer cells. Bioinformatics analysis results showed that LRH1 was potential direct target of miR-10b, which was further confirmed by a dual-luciferase activity reporter assay. LRH1 knocked down by small interfering RNA (siRNA) significantly inhibited prostate cancer cell proliferation and invasion. miR-10b was overexpressed in prostate cancer cells through transfection of miR-10b mimics and overexpressed miR-10b significantly inhibited LRH1 expression, cell proliferation and invasion. In conclusion LRH1 is implicated in prostate cancer, and miR-10b-mediated suppression of LRH1 can be a novel treatment strategy of prostate cancer.