Pretreatment total serum protein is a significant prognostic factor for the outcome of patients with peripheral T/natural killer-cell lymphomas

被引：37

作者：

Watanabe, Takashi ^{[1
]}

Kinoshita, Tomohiro ^{[2
]}

Itoh, Kuniaki ^{[3
]}

Yoshimura, Kenichi ^{[4
]}

Ogura, Michinori ^{[5
]}

Kagami, Yoshitoyo ^{[6
]}

Yamaguchi, Motoko ^{[7
]}

Kurosawa, Mitsutoshi ^{[8
]}

Tsukasaki, Kunihiro ^{[9
]}

Kasai, Masaharu ^{[10
]}

Tobinai, Kensei

Kaba, Harumi ^{[4
]}

Mukai, Kiyoshi ^{[11
]}

Nakamura, Shigeo ^{[12
,13
]}

Ohshima, Koichi ^{[14
]}

Hotta, Tomomitsu ^{[15
]}

Shimoyama, Masanori

机构：

[1] Natl Canc Ctr, Div Hematol, Chuo Ku, Tokyo 1040045, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Hematol & Oncol, Nagoya, Aichi 4648601, Japan

[3] Natl Canc Ctr Hosp E, Div Hematol & Oncol, Kashiwa, Chiba, Japan

[4] Natl Canc Ctr, Ctr Canc Control & Informat Serv, Clin Trials & Practice Support Div, Tokyo 104, Japan

[5] Nagoya Daini Red Cross Hosp, Dept Hematol & Oncol, Nagoya, Aichi, Japan

[6] Aichi Canc Ctr Hosp, Dept Hematol & Cell Therapy, Nagoya, Aichi 464, Japan

[7] Mie Univ, Grad Sch Med, Dept Hematol & Oncol, Tsu, Mie 514, Japan

[8] Hokkaido Canc Ctr, Natl Hosp Org, Dept Hematol, Sapporo, Hokkaido, Japan

[9] Nagasaki Univ Hosp, Atom Bomb Dis Inst, Dept Hematol & Mol Med, Nagasaki, Japan

[10] Sapporo Hokuyu Hosp, Dept Hematol, Sapporo, Hokkaido, Japan

[11] Tokyo Med Univ, Dept Pathol, Tokyo, Japan

[12] Nagoya Univ Hosp, Dept Pathol, Nagoya, Aichi, Japan

[13] Nagoya Univ Hosp, Clin Labs, Nagoya, Aichi, Japan

[14] Kurume Univ, Sch Med, Dept Pathol 1, Fukuoka, Japan

[15] Nagoya Med Ctr, Dept Hematol & Oncol, Nagoya, Aichi, Japan

来源：

LEUKEMIA & LYMPHOMA | 2010年 / 51卷 / 05期

关键词：

NON-HODGKINS-LYMPHOMA; DETUDE-DES-LYMPHOMES; EPSTEIN-BARR-VIRUS; PHASE-II; EXPRESSION; CLASSIFICATION; FEATURES; INDEX; CHEMOTHERAPY; SURVIVAL;

D O I：

10.3109/10428191003721359

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peripheral T- and NK-cell lymphomas (PT/NKCLs) are relatively rare, and few studies have validated the International Prognostic Index (IPI) for PT/NKCLs in prospective clinical trials. Histopathological specimens from 136 patients, enrolled in six prospective multicenter trials of doxorubicin-containing regimens, with PT/NKCLs were reviewed by six hematopathologists following the WHO classification. This combined analysis demonstrated that the IPI was not predictive of prognosis for patients with PT/NKCLs as previously shown by GELA. In a univariate analysis, low total serum protein (TP) and albumin levels, gastrointestinal tract involvement, and histologic subtype (extranodal NK/T-cell lymphoma, nasal type, and peripheral T-cell lymphoma, unspecified) were significantly associated with reduced survival. In a multivariate analysis, TP (p = 0.004) and histologic subtype (p = 0.024) remained significant. We discuss the need to establish the importance and meaning of TP and to develop new strategies for patients with PT/NKCLs allowing for TP, especially with worse histologic subtypes.</.

引用

页码：813 / 821

页数：9

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