Phytochemicals of Pogostemon Cablin (Blanco) Benth. aqueous extract: Their xanthine oxidase inhibitory activities

被引：24

作者：

Liu, Fang ^{[1
,2
]}

Deng, Chao ^{[1
]}

Cao, Wei ^{[1
]}

Zeng, Guangyao ^{[1
]}

Deng, Xu ^{[1
]}

Zhou, Yingjun ^{[1
]}

机构：

[1] Cent S Univ, Coll Pharm, Changsha 410013, Hunan, Peoples R China

[2] Xiangnan Univ, Coll Pharm, Chenzhou 423043, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 89卷

关键词：

Pogostemon cablin (Blanco) Benth; Water extract; Phytochemicals; Xanthine oxidase inhibition; PHENOLIC GLYCOSIDES; FEBUXOSTAT; HYPERURICEMIA; LEAVES; GOUT;

D O I：

10.1016/j.biopha.2017.01.040

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Bioassay-guided fractionation of the aerial part of P. cablin revealed that fraction A3 of the water extract exhibited significant xanthine oxidase inhibitory activities (IC50 = 85.42 +/- 1.71 mg/mL), which further led to the isolation of ten more bioactive compounds, including two new compounds (1 and 2). The structures of compounds 1 and 2 were elucidated by extensive spectral analysis. It is revealed that flavonoids and phenolic compounds were found to be responsible for the xanthine oxidase inhibitory activities of P. cablin. Especially, rosmarinic acid was found to be with potent XO inhibitory activity (IC50 = 8.53 +/- 0.91 mg/mL). (C) 2017 Published by Elsevier Masson SAS.

引用

页码：544 / 548

页数：5

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