Thrombotic risk in patients with COVID-19

被引：8

作者：

Pancaldi, Edoardo ^{[1
]}

Pascariello, Greta ^{[1
]}

Cimino, Giuliana ^{[1
]}

Cersosimo, Angelica ^{[1
]}

Amore, Ludovica ^{[1
]}

Alghisi, Fabio ^{[1
]}

Bernardi, Nicola ^{[1
]}

Calvi, Emiliano ^{[1
]}

Lombardi, Carlo Mario ^{[1
]}

Vizzardi, Enrico ^{[1
]}

Metra, Marco ^{[1
]}

机构：

[1] Univ Brescia, Dept Med & Surg Special Radiol Sci & Publ Hlth, Cardiol Unit, I-23123 Brescia, Italy

来源：

REVIEWS IN CARDIOVASCULAR MEDICINE | 2021年 / 22卷 / 02期

关键词：

Thrombosis; COVID-19; Pulmonary embolism; Endothelitis; Coagulopathy; VENOUS THROMBOEMBOLISM; PULMONARY-EMBOLISM; MORTALITY; DISEASE; COMPLICATIONS; METAANALYSIS; PNEUMONIA; PLATELETS; TRAPS;

D O I：

10.31083/j.rcm2202035

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Emerging evidences prove that the ongoing pandemic of coronavirus disease 2019 (COVID-19) is strictly linked to coagulopathy even if pneumonia appears as the major clinical manifestation. The exact incidence of thromboembolic events is largely unknown, so that a relative significant number of studies have been performed in order to explore thrombotic risk in COVID-19 patients. Cytokine storm, mediated by pro-inflammatory interleukins, tumor necrosis factor alpha and elevated acute phase reactants, is primarily responsible for COVID-19-associated hypercoagulopathy. Also comorbidities, promoting endothelial dysfunction, contribute to a higher thromboembolic risk. In this review we aim to investigate epidemiology and clarify the pathophysiological pathways underlying hypercoagulability in COVID-19 patients, providing indications on the prevention of thromboembolic events in COVID-19. Furthermore we aim to reassume the pathophysiological paths involved in COVID-19 infection.

引用

页码：277 / 286

页数：10

共 75 条

[1] COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection [J].

Al-Samkari, Hanny ;

Leaf, Rebecca S. Karp ;

Dzik, Walter H. ;

Carlson, Jonathan C. T. ;

Fogerty, Annemarie E. ;

Waheed, Anem ;

Goodarzi, Katayoon ;

Bendapudi, Pavan K. ;

Bornikova, Larissa ;

Gupta, Shruti ;

Leaf, David E. ;

Kuter, David J. ;

Rosovsky, Rachel P. .

BLOOD, 2020, 136 (04) :489-500

[2] Pulmonary embolism in patients with COVID-19: characteristics and outcomes in the Cardio-COVID Italy multicenter study [J].

Ameri, Pietro ;

Inciardi, Riccardo M. ;

Di Pasquale, Mattia ;

Agostoni, Piergiuseppe ;

Bellasi, Antonio ;

Camporotondo, Rita ;

Canale, Claudia ;

Carubelli, Valentina ;

Carugo, Stefano ;

Catagnano, Francesco ;

Danzi, Giambattista ;

Dalla Vecchia, Laura ;

Giovinazzo, Stefano ;

Gnecchi, Massimiliano ;

Guazzi, Marco ;

Iorio, Anita ;

La Rovere, Maria Teresa ;

Leonardi, Sergio ;

Maccagni, Gloria ;

Mapelli, Massimo ;

Margonato, Davide ;

Merlo, Marco ;

Monzo, Luca ;

Mortara, Andrea ;

Nuzzi, Vincenzo ;

Piepoli, Massimo ;

Porto, Italo ;

Pozzi, Andrea ;

Provenzale, Giovanni ;

Sarullo, Filippo ;

Sinagra, Gianfranco ;

Tedino, Chiara ;

Tomasoni, Daniela ;

Volterrani, Maurizio ;

Zaccone, Gregorio ;

Lombardi, Carlo Mario ;

Senni, Michele ;

Metra, Marco .

CLINICAL RESEARCH IN CARDIOLOGY, 2021, 110 (07) :1020-1028

[3] Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. Interim guidance [J].

不详 .

PEDIATRIA I MEDYCYNA RODZINNA-PAEDIATRICS AND FAMILY MEDICINE, 2020, 16 (01) :9-26

[4]

[Anonymous], 2020, [No title captured]

[5] Platelets and infection - an emerging role of platelets in viral infection [J].

Assinger, Alice .

FRONTIERS IN IMMUNOLOGY, 2014, 5

[6] Anticoagulation in COVID-19 [J].

Atallah, Bassam ;

Mallah, Saad I. ;

AlMahmeed, Wael .

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, 2020, 6 (04) :260-261

[7] Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum [J].

Barnes, Geoffrey D. ;

Burnett, Allison ;

Allen, Arthur ;

Blumenstein, Marilyn ;

Clark, Nathan P. ;

Cuker, Adam ;

Dager, William E. ;

Deitelzweig, Steven B. ;

Ellsworth, Stacy ;

Garcia, David ;

Kaatz, Scott ;

Minichiello, Tracy .

JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2020, 50 (01) :72-81

[8] American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy [J].

Bates, Shannon M. ;

Rajasekhar, Anita ;

Middeldorp, Saskia ;

McLintock, Claire ;

Rodger, Marc A. ;

James, Andra H. ;

Vazquez, Sara R. ;

Greer, Ian A. ;

Riva, John J. ;

Bhatt, Meha ;

Schwab, Nicole ;

Barrett, Danielle ;

LaHaye, Andrea ;

Rochwerg, Bram .

BLOOD ADVANCES, 2018, 2 (22) :3317-3359

[9]

Bernardi Nicola, 2020, JACC Case Rep, V2, P1359, DOI 10.1016/j.jaccas.2020.06.008

[10] Pulmonary embolism in patients with COVID-19 pneumonia [J].

Bompard, Florian ;

Monnier, Hippolyte ;

Saab, Ines ;

Tordjman, Mickael ;

Abdoul, Hendy ;

Fournier, Laure ;

Sanchez, Olivier ;

Lorut, Christine ;

Chassagnon, Guillaume ;

Revel, Marie-Pierre .

EUROPEAN RESPIRATORY JOURNAL, 2020, 56 (01)

← 1 2 3 4 5 6 7 8 →