N-(4-Methoxyphenyl)-substituted bicyclic isothioureas: effect on morphology of cancer cells

被引：5
|
作者：
Evdokimova, Anna, V [1 ]
Alexeev, Alexander A. [1 ]
Nurieva, Evgeniya, V [1 ]
Milaeva, Elena R. [1 ,2 ]
Kuznetsov, Sergei A. [3 ]
Zefirova, Olga N. [1 ,2 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia
[2] Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka 142432, Moscow Region, Russia
[3] Univ Rostock, Inst Biol Sci, D-18059 Rostock, Germany
来源：
MENDELEEV COMMUNICATIONS | 2021年 / 31卷 / 03期
基金：
俄罗斯科学基金会;
关键词：
thiazolin-2-amines; cycloalka[d]thiazoles; thioureas; isothioureas; heterocyclization; verubulin; lung carcinoma A549; cancer cell morphology;
D O I：
10.1016/j.mencom.2021.05.003
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Bicyclic isothioureas of N-(4-methoxyphenyl)-2-aminocyclo-alkane[d]thiazole type were obtained using intramolecular electrophilic cyclization of N-(cycloalk-2-enyl)-N'- (4-methoxyphenyl)thioureas. Isothiourea fused with seven-membered ring caused noticeable changes of the morphology of human lung carcinoma cells A549, but without affecting their microtubule net.
引用
收藏
页码：288 / 290
页数：3
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