Synthesis of Aza-Fused Polycyclic Quinolines through Copper-Catalyzed Cascade Reactions

被引：76

作者：

Cai, Qian ^{[1
,2
,3
]}

Li, Zhengqiu ^{[4
]}

Wei, Jiajia ^{[1
,2
,3
]}

Fu, Liangbin ^{[1
,2
,3
]}

Ha, Chengyong ^{[4
]}

Pei, Duanqing ^{[1
,2
,3
]}

Ding, Ke ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Key Lab Regenerat Biol, Guangzhou Inst Biomed, Guangzhou 510530, Guangdong, Peoples R China

[2] Chinese Acad Sci, Inst Biol Chem, Guangzhou Inst Biomed, Guangzhou 510530, Guangdong, Peoples R China

[3] Chinese Acad Sci, Guangzhou Inst Hlth, Guangzhou 510530, Guangdong, Peoples R China

[4] Chinese Acad Sci, Key Lab Cellulose & Lignocellulos Chem, Guangzhou Inst Chem, Guangzhou 510530, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 07期

关键词：

COUPLING REACTIONS; EFFICIENT SYNTHESIS; BOND FORMATION; C-N; DERIVATIVES; PHENANTHRENES; CYCLIZATIONS; HETEROARENES; HETEROCYCLES; CHEMISTRY;

D O I：

10.1021/ol1002225

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and efficient method for the synthesis of aza-fused polycyclic quinolines (e.g., benzimidazo[1,2-a]quinolines) is described. This protocol Includes an Intermolecular condensation followed by a copper-catalyzed Intramolecular C-N coupling reaction. The method is applied to a wide range of 2-iodo, 2-bromo, and 2-chloro aryl aldehyde substrates to yield the aza-fused polycyclic quinolines in good yields.

引用

页码：1500 / 1503

页数：4

共 37 条

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