Colistin-Resistant Acinetobacter baumannii Clinical Strains with Deficient Biofilm Formation

被引：36

作者：

Dafopoulou, Konstantina ^{[1
,2
]}

Xavier, Basil Britto ^{[2
]}

Hotterbeekx, An ^{[2
]}

Janssens, Lore ^{[2
]}

Lammens, Christine ^{[2
]}

De, Emmanuelle ^{[3
]}

Goossens, Herman ^{[2
]}

Tsakris, Athanasios ^{[1
,2
]}

Malhotra-Kumar, Surbhi

Pournaras, Spyros ^{[1
]}

机构：

[1] Univ Athens, Dept Microbiol, Athens 11528, Greece

[2] Univ Antwerp, Lab Med Microbiol, Vaccine & Infect Dis Inst, B-2020 Antwerp, Belgium

[3] Univ Rouen, CNRS UMR 6270, Polymers Biopolymers & Surfaces Lab, Rouen, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 03期

关键词：

PSEUDOMONAS-AERUGINOSA; VIRULENCE; MECHANISMS; COST;

D O I：

10.1128/AAC.02518-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In two pairs of clinical colistin-susceptible/colistin-resistant (Cst(s)/Cst(r)) Acinetobacter baumannii strains, the Cst(r) strains showed significantly decreased biofilm formation in static and dynamic assays (P < 0.001) and lower relative fitness (P < 0.05) compared with those of the Cst(s) counterparts. The whole-genome sequencing comparison of strain pairs identified a mutation converting a stop codon to lysine (*241K) in LpsB (involved in lipopolysaccharide [LPS] synthesis) in one Cst(r) strain and a frameshift mutation in CarO and the loss of a 47,969-bp element containing multiple genes associated with biofilm production in the other.

引用

页码：1892 / 1895

页数：4

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