ADP receptors in platelet activation and aggregation

被引：0
|
作者：
Hoylaerts, MF [1 ]
Oury, C [1 ]
Toth-Zsamboki, E [1 ]
Vermylen, J [1 ]
机构：
[1] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium
来源：
PLATELETS | 2000年 / 11卷 / 06期
关键词：
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
ADP plays a central role in platelet aggregation. Activation of platelets via ADP proceeds via three membrane receptor proteins, two of which are coupled to a G protein and the third one constituting an ion channel mediating rapid Ca2+-influx. Via Ca2+-mobilization, the Gq-coupled P2Y(1) receptor acts in concert with the Gi-coupled P2T(AC) receptor, which functions by lowering intracellular cAMP levels. The importance of Ca2+-influx via the P2X(1) ion channel remains to be elucidated.
引用
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页码：307 / 309
页数：3
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