ADP receptors in platelet activation and aggregation

被引：0
|
作者：
Hoylaerts, MF [1 ]
Oury, C [1 ]
Toth-Zsamboki, E [1 ]
Vermylen, J [1 ]
机构：
[1] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium
来源：
PLATELETS | 2000年 / 11卷 / 06期
关键词：
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
ADP plays a central role in platelet aggregation. Activation of platelets via ADP proceeds via three membrane receptor proteins, two of which are coupled to a G protein and the third one constituting an ion channel mediating rapid Ca2+-influx. Via Ca2+-mobilization, the Gq-coupled P2Y(1) receptor acts in concert with the Gi-coupled P2T(AC) receptor, which functions by lowering intracellular cAMP levels. The importance of Ca2+-influx via the P2X(1) ion channel remains to be elucidated.
引用
收藏
页码：307 / 309
页数：3
相关论文
共 50 条
  • [1] Activation of ADP receptors and platelet function
    Gachet, C
    Hechler, B
    Leon, C
    Vial, C
    Leray, C
    Ohlmann, P
    Cazenave, JP
    THROMBOSIS AND HAEMOSTASIS, 1997, 78 (01) : 271 - 275
  • [2] PLATELET FIBRINOGEN RECEPTORS AND ADP-INDUCED PLATELET-AGGREGATION
    MARGUERIE, G
    PLOW, E
    NOUVELLE REVUE FRANCAISE D HEMATOLOGIE, 1980, 22 : R7 - R7
  • [3] MODULATION OF PLATELET-AGGREGATION BY AGENTS THAT INTERFERE WITH THE BINDING OF ADP TO PLATELET RECEPTORS
    LEGRAND, C
    DUBERNARD, V
    NURDEN, AT
    EUROPEAN HEART JOURNAL, 1983, 4 : 3 - 3
  • [4] The platelet ADP receptors
    Cattaneo, M
    Gachet, C
    HAEMATOLOGICA, 2001, 86 (04) : 346 - 348
  • [5] ROLE OF ADP RECEPTORS IN EPINEPHRINE-INDUCED PLATELET ACTIVATION
    FIGURES, WR
    STRIMPLER, AM
    SCEARCE, M
    MILLS, JK
    WACHTFOGEL, YT
    COLMAN, RF
    COLMAN, RW
    FEDERATION PROCEEDINGS, 1984, 43 (03) : 660 - 660
  • [6] ADP-PLATELET AGGREGATION
    SALZMAN, EW
    THROMBOSIS ET DIATHESIS HAEMORRHAGICA, 1967, S : 197 - &
  • [7] PLATELET AGGREGATION BY ADP AND THROMBIN
    NIEWIARO.S
    THOMAS, DP
    NATURE, 1966, 212 (5070) : 1544 - &
  • [8] Coumarin Derivatives Inhibit ADP-Induced Platelet Activation and Aggregation
    Lu, Ping-Hsun
    Liao, Tzu-Hsien
    Chen, Yau-Hung
    Hsu, Yeng-Ling
    Kuo, Chan-Yen
    Chan, Chuan-Chi
    Wang, Lu-Kai
    Chern, Ching-Yuh
    Tsai, Fu-Ming
    MOLECULES, 2022, 27 (13):
  • [9] Platelet ADP Receptors and their Antagonists
    Benoit, Patricia
    Dogne, Jean-Michel
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2003, 3 (02) : 145 - 148
  • [10] The platelet ATP and ADP receptors
    Oury, C
    Toth-Zsamboki, E
    Vermylen, J
    Hoylaerts, MF
    CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (07) : 859 - 875
12345