Decarboxylative C-H Cross-Coupling of Azoles

被引：231
|
作者：
Zhang, Fengzhi [1 ]
Greaney, Michael F. [1 ]
机构：
[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 15期
基金：
英国工程与自然科学研究理事会;
关键词：
catalysis; cross-coupling; C-H activation; heterocycles; palladium; CATALYZED DIRECT ARYLATION; AROMATIC CARBOXYLIC-ACIDS; BIARYL SYNTHESIS; BOND-CLEAVAGE; ARYL HALIDES; PROTODECARBOXYLATION; PALLADATION; OLEFINATION;
D O I：
10.1002/anie.200906921
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Côte d'Azole: The title reaction demon-strates the use of diverse oxazoles 2 as suitable substrates in cross-coupling reactions with azole-5-carboxylic acids 1 under palladium catalysis in the presence of copper carbonate. The reaction is successful for the synthesis of a range of bis(azole)s, and has been applied to the convergent synthesis of challenging poly azoles (dcpe = bis(dicyclohexylphosphi-no)ethane, DMSO = dimethyl sulfoxide, M.S. = molecular sieves). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2768 / 2771
页数：4
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