Total synthesis of marine sponge bis(indole) alkaloids of the topsentin class

被引：47

作者：

Guinchard, Xavier ^{[1
]}

Vallee, Yannick ^{[1
]}

Denis, Jean-Noel ^{[1
]}

机构：

[1] Univ Grenoble 1, Dept Chim Mol SERCO, UMR 5250, ICMG FR 2607,CNRS, F-38041 Grenoble 9, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 10期

关键词：

D O I：

10.1021/jo070286r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The synthesis of four natural bis(indole) alkaloids of topsentin class 1 and 2 is described. Their bis(indole) alpha-carbonylimidazoline and subsequently bis(indole) alpha-carbonylimidazole moieties have been built via the condensation between indolic alpha-ketothioimidate salts 4 and 1-(indol-3'-yl)-1,2-diaminoethane 3. This compound results from the beta-amino indolic hydroxylamine 5 by a two-step sequence. This is the first total synthesis of compounds 1d, 2a, and 2b.

引用

页码：3972 / 3975

页数：4

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