Recommendations for the clinical and laboratory diagnosis of VITT against COVID-19: Communication from the ISTH SSC Subcommittee on Platelet Immunology

被引：124

作者：

Nazy, Ishac ^{[1
,2
]}

Sachs, Ulrich J. ^{[3
]}

Arnold, Donald M. ^{[1
,2
]}

McKenzie, Steven E. ^{[4
]}

Choi, Phil ^{[5
,6
]}

Althaus, Karina ^{[7
,8
]}

Ahlen, Maria Therese ^{[9
]}

Sharma, Ruchika ^{[10
]}

Grace, Rachael F. ^{[11
]}

Bakchoul, Tamam ^{[12
]}

机构：

[1] McMaster Univ, Michael G DeGroote Sch Med, Dept Med, HSC 3H53,1280 Main St West, Hamilton, ON L8S 4K1, Canada

[2] McMaster Ctr Transfus Res, Hamilton, ON, Canada

[3] Giessen Univ Hosp, Dept Thrombosis & Haemostasis, Giessen, Germany

[4] Thomas Jefferson Univ, Cardeza Fdn Hematol Res, Philadelphia, PA 19107 USA

[5] Canberra Hosp, Haematol Dept, Canberra, ACT, Australia

[6] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT, Australia

[7] Univ Tubingen, Med Fac Tuebingen, Transfus Med, Tubingen, Germany

[8] Ctr Clin Transfus Med Tuebingen ZKT gGmbH, Tubingen, Germany

[9] Univ Hosp North Norway, Norwegian Natl Unit Platelet Immunol, Tromso, Norway

[10] Med Coll Wisconsin, Versiti BloodCtr Wisconsin Pediat Hematol Oncol, Milwaukee, WI 53226 USA

[11] Harvard Med Sch, Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA 02115 USA

[12] Univ Hosp Tuebingen, Med Fac Tuebingen, Inst Clin & Expt Transfus Med, Tubingen, Germany

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2021年 / 19卷 / 06期

关键词：

AstraZeneca ChadOx1 nCov-19 vaccine; COVID-19; platelet activation; thrombocytopenia; thrombosis; HEPARIN-INDUCED THROMBOCYTOPENIA; CONFIRMATION; IDENTIFICATION; ANTIBODIES; TOOL;

D O I：

10.1111/jth.15341

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vaccine administration is under way worldwide to combat the current COVID-19 pandemic. The newly developed vaccines are highly effective with minimal adverse effects. Recently, the AstraZeneca ChadOx1 nCov-19 vaccine has raised public alarm with concerns regarding the rare, but serious, development of thrombotic events, now known as vaccine-induced immune thrombotic thrombocytopenia (VITT). These thrombotic events appear similar to heparin-induced thrombocytopenia, both clinically and pathologically. In this manuscript, the ISTH SSC Subcommittee on Platelet Immunology outlines guidelines on how to recognize, diagnose and manage patients with VITT.

引用

页码：1585 / 1588

页数：4

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