What are oligomerization domains good for?

被引：31

作者：

Engel, J ^{[1
]}

Kammerer, RA ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, Biophys Chem Abt, CH-4056 Basel, Switzerland

来源：

MATRIX BIOLOGY | 2000年 / 19卷 / 04期

关键词：

oligomer formation; multivalency; binding affinity; structural stability; coiled-coil domains; collagen triple helix; foldon; protein engineering;

D O I：

10.1016/S0945-053X(00)00075-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Collagen triple helices, coiled coils and other oligomerization domains mediate the subunit assembly of a large number of proteins. Oligomerization leads to functional advantages of multivalency and high binding strength, increased structure stabilization and combined functions of different domains. These features seen in naturally occurring proteins can be engineered by protein design by combining oligomerization domains with functional domains. (C) 2000 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved.

引用

页码：283 / 288

页数：6

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