Molecular and Clinical Insights into the Role and Significance of Mutated DNA Repair Genes in Bladder Cancer

被引：21

作者：

Abbosh, Philip H. ^{[1
,2
]}

Plimack, Elizabeth R. ^{[3
]}

机构：

[1] Fox Chase Canc Ctr, Inst Canc Res, 7701 Burholme Ave, Philadelphia, PA 19111 USA

[2] Einstein Med Ctr, Dept Urol, Philadelphia, PA USA

[3] Fox Chase Canc Ctr, Dept Hematol Oncol, 7701 Burholme Ave, Philadelphia, PA 19111 USA

来源：

BLADDER CANCER | 2018年 / 4卷 / 01期

关键词：

DNA damage response; DNA damage repair; cisplatin; immunotherapy; chemoresponse; bladder cancer; upper tract urothelial carcinoma; NONPOLYPOSIS COLORECTAL-CANCER; SOMATIC ERCC2 MUTATIONS; MISMATCH-REPAIR; GENOMIC CHARACTERIZATION; XERODERMA-PIGMENTOSUM; PD-1; BLOCKADE; CISPLATIN; IDENTIFICATION; SENSITIVITY; TRICHOTHIODYSTROPHY;

D O I：

10.3233/BLC-170129

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA damage response and repair genes (DDR genes) are commonly mutated in bladder cancer. The biological impact of these mutations is an area of intense basic, translational, and clinical interest. As next generation sequencing increases its foothold in the treatment of localized and advanced bladder cancer, the role of DDR genes will continue to evolve. We review the inventory and biology of DDR genes in bladder cancer and describe known and candidate roles for loss of DDR genes to engender therapeutic susceptibilities to various anti-cancer agents.

引用

页码：9 / 18

页数：10

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