Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery

被引：6

作者：

Silvestri, Alessandra ^{[1
]}

Vicente, Francisca ^{[2
,3
]}

Vicent, Maria J. ^{[4
,5
]}

Stechmann, Bahne ^{[1
]}

Fecke, Wolfgang ^{[1
]}

机构：

[1] EU OPENSCREEN ERIC, Berlin, Germany

[2] Fdn MEDINA, Screening & New Targets Dept, Granada, Spain

[3] Fdn MEDINA, Screening Microbial Extracts Nat Prod Synthet Cpd, Granada, Spain

[4] Principe Felipe Res Ctr, Polymer Therapeut Lab, Valencia, Spain

[5] Principe Felipe Res Ctr, Screening Platform, Valencia, Spain

来源：

DRUG DISCOVERY TODAY | 2021年 / 26卷 / 06期

关键词：

3-DIMENSIONAL CELL-CULTURE; MULTICELLULAR TUMOR SPHEROIDS; ON-A-CHIP; MICROPHYSIOLOGICAL SYSTEMS; MICROFLUIDIC PLATFORM; ORGANOID BIOBANK; CAPTURES DISEASE; STEM-CELLS; 3D CULTURE; LIVER;

D O I：

10.1016/j.drudis.2021.02.024

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The success of preclinical drug discovery strongly relies on the ability of experimental models to resemble human pathophysiology. The number of compounds receiving approval for clinical use is limited, and this has led to the development of more physiologically relevant cellular models aimed at making preclinical results more prone to be successfully translated into clinical use. In this review, we summarize the technologies available in the field of high-throughput screening (HTS) using complex cellular models, and describe collaborative initiatives, such as EU-OPENSCREEN, which can efficiently support researchers to easily access state-of-the-art chemical biology platforms for improving the drug discovery process.

引用

页码：1369 / 1381

页数：13