The role of tumor-associated macrophages in primary hepatocellular carcinoma and its related targeting therapy

被引：33

作者：

Deng, Lu ^{[1
]}

He, Kang ^{[1
]}

Pan, Yixiao ^{[1
]}

Wang, Hai ^{[1
]}

Luo, Yi ^{[1
]}

Xia, Qiang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Liver Surg, Shanghai, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2021年 / 18卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Tumor-associated macrophages; hepatocellular carcinoma; therapy; EPITHELIAL-MESENCHYMAL TRANSITION; PROMOTE EXPANSION; MONOCLONAL-ANTIBODY; ACTIVATED MONOCYTES; INITIATING CELLS; MYELOID CELLS; HCC CELLS; T-CELLS; LIVER; EXPRESSION;

D O I：

10.7150/ijms.56003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Liver macrophages consist of ontogenically distinct populations termed Kupffer cells and monocyte-derived macrophages. Tumor-associated macrophages (TAMs) inhepatocellularcarcinoma (HCC) play a prominent role in tumormicroenvironment by presenting M1(induced by IFN gamma along with LPS) and M2(induced by IL-4 and IL13) polarization. Although TAMs are involved in tumor immune surveillance during the course of HCC, they contribute to tumour progression at different levels by inhibiting the anti-tumor immune response, promoting the generation of blood vessels and lymphatic vessels, and supporting the proliferation and survival of tumor cells. In this paper, the multiple functions of TAMs in HCC were reviewed to provide assistance for future researches about therapeutic approaches.

引用

页码：2109 / 2116

页数：8

共 89 条

[1] A complex secretory program orchestrated by the inflammasome controls paracrine senescence [J].

Acosta, Juan Carlos ;

Banito, Ana ;

Wuestefeld, Torsten ;

Georgilis, Athena ;

Janich, Peggy ;

Morton, Jennifer P. ;

Athineos, Dimitris ;

Kang, Tae-Won ;

Lasitschka, Felix ;

Andrulis, Mindaugas ;

Pascual, Gloria ;

Morris, Kelly J. ;

Khan, Sadaf ;

Jin, Hong ;

Dharmalingam, Gopuraja ;

Snijders, Ambrosius P. ;

Carroll, Thomas ;

Capper, David ;

Pritchard, Catrin ;

Inman, Gareth J. ;

Longerich, Thomas ;

Sansom, Owen J. ;

Aznar Benitah, Salvador ;

Zender, Lars ;

Gil, Jesus .

NATURE CELL BIOLOGY, 2013, 15 (08) :978-U221

[2] Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma [J].

Ao, Jian-Yang ;

Zhu, Xiao-Dong ;

Chai, Zong-Tao ;

Cai, Hao ;

Zhang, Yuan-Yuan ;

Zhang, Ke-Zhi ;

Kong, Ling-Qun ;

Zhang, Ning ;

Ye, Bo-Gen ;

Ma, De-Ning ;

Sun, Hui-Chuan .

MOLECULAR CANCER THERAPEUTICS, 2017, 16 (08) :1544-1554

[3] Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy [J].

Barkal, Amira A. ;

Weiskopf, Kipp ;

Kao, Kevin S. ;

Gordon, Sydney R. ;

Rosental, Benyamin ;

Yiu, Ying Y. ;

George, Benson M. ;

Markovic, Maxim ;

Ring, Nan G. ;

Tsai, Jonathan M. ;

McKenna, Kelly M. ;

Ho, Po Yi ;

Cheng, Robin Z. ;

Chen, James Y. ;

Barkal, Layla J. ;

Ring, Aaron M. ;

Weissman, Irving L. ;

Maute, Roy L. .

NATURE IMMUNOLOGY, 2018, 19 (01) :76-+

[4] Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions [J].

Beattie, Lynette ;

Sawtell, Amy ;

Mann, Jason ;

Frame, Teija C. M. ;

Teal, Bianca ;

Rivera, Fabian de Labastida ;

Brown, Najmeeyah ;

Walwyn-Brown, Katherine ;

Moore, John W. J. ;

MacDonald, Sandy ;

Lim, Eng-Kiat ;

Dalton, Jane E. ;

Engwerda, Christian R. ;

MacDonald, Kelli P. ;

Kaye, Paul M. .

JOURNAL OF HEPATOLOGY, 2016, 65 (04) :758-768

[5] Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm [J].

Biswas, Subhra K. ;

Mantovani, Alberto .

NATURE IMMUNOLOGY, 2010, 11 (10) :889-896

[6] Hepatocellular carcinoma: clinical frontiers and perspectives [J].

Bruix, Jordi ;

Gores, Gregory J. ;

Mazzaferro, Vincenzo .

GUT, 2014, 63 (05) :844-855

[7] Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T [J].

Burga, Rachel A. ;

Thorn, Mitchell ;

Point, Gary R. ;

Guha, Prajna ;

Nguyen, Cang T. ;

Licata, Lauren A. ;

DeMatteo, Ronald P. ;

Ayala, Alfred ;

Espat, N. Joseph ;

Junghans, Richard P. ;

Katz, Steven C. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2015, 64 (07) :817-829

[8] Colony-stimulating factor-1-induced AIF1 expression in tumor-associated macrophages enhances the progression of hepatocellular carcinoma [J].

Cai, Hao ;

Zhu, Xiao-Dong ;

Ao, Jian-Yang ;

Ye, Bo-Gen ;

Zhang, Yuan-Yuan ;

Chai, Zong-Tao ;

Wang, Cheng-Hao ;

Shi, Wen-Kai ;

Cao, Man-qing ;

Li, Xiao-Long ;

Sun, Hui-Chuan .

ONCOIMMUNOLOGY, 2017, 6 (09)

[9] CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study [J].

Cassier, Philippe A. ;

Italiano, Antoine ;

Gomez-Roca, Carlos A. ;

Le Tourneau, Christophe ;

Toulmonde, Maud ;

Cannarile, Michael A. ;

Ries, Carola ;

Brillouet, Anne ;

Mueller, Claudia ;

Jegg, Anna-Maria ;

Broeske, Ann-Marie ;

Dembowski, Markus ;

Bray-French, Katharine ;

Freilinger, Christine ;

Meneses-Lorente, Georgina ;

Baehner, Monika ;

Harding, Ross ;

Ratnayake, Jayantha ;

Abiraj, Keelara ;

Gass, Nathalie ;

Noh, Karen ;

Christen, Randolph D. ;

Ukarma, Lidia ;

Bompas, Emmanuelle ;

Delord, Jean-Pierre ;

Blay, Jean-Yves ;

Ruettinger, Dominik .

LANCET ONCOLOGY, 2015, 16 (08) :949-956

[10] Upregulation of B7-H1 expression is associated with macrophage infiltration in hepatocellular carcinomas [J].

Chen, Jie ;

Li, Guosheng ;

Meng, Hong ;

Fan, Yuchen ;

Song, Yonghong ;

Wang, Shurong ;

Zhu, Faliang ;

Guo, Chun ;

Zhang, Lining ;

Shi, Yongyu .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2012, 61 (01) :101-108

← 1 2 3 4 5 6 7 8 9 →