Cellular reprogramming and the rise of rejuvenation biotech

被引：12

作者：

de Magalhaes, Joao Pedro ^{[1
]}

Ocampo, Alejandro ^{[2
]}

机构：

[1] Univ Liverpool, Inst Ageing & Chron Dis, Integrat Genom Ageing Grp, Liverpool, England

[2] Univ Lausanne, Dept Biomed Sci, Lausanne, Switzerland

来源：

TRENDS IN BIOTECHNOLOGY | 2022年 / 40卷 / 06期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

Work in the lab of J.P.M. is supported by grants from the Wellcome Trust ( 208375/Z/17/Z ); LongeCity; and the Biotechnology and Biological Sciences Research Council ( BB/R014949/1 and BB/V010123/1 ).Work in the lab of J.P.M. is supported by grants from the Wellcome Trust (208375/Z/17/Z); and the Biotechnology and Biological Sciences Research Council (BB/R014949/1 and BB/V010123/1). J.P.M. is an advisor/consultant for the Longevity Vision Fund; Centaura; NOVOS; YouthBio Therapeutics and the founder of Magellan Science Ltd; a company providing consulting services in longevity science. A.O. is founder of Longevity Consultancy Group; a company providing consulting services in longevity science;

D O I：

10.1016/j.tibtech.2022.01.011

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cells can be rejuvenated and bio-logical clocks reset using cellular reprogramming. A growing number of companies now aim to use cellu-lar reprogramming to develop thera-pies for rejuvenating human beings. Can the 'young' science of rejuve-nation, currently mostly based on in vitro studies, drive a new biotech field toward clinical applications?

引用

页码：639 / 642

页数：4

共 15 条

[1] Reprogramming in vivo produces teratomas and iPS cells with totipotency features [J].

Abad, Maria ;

Mosteiro, Lluc ;

Pantoja, Cristina ;

Canamero, Marta ;

Rayon, Teresa ;

Ors, Inmaculada ;

Grana, Osvaldo ;

Megias, Diego ;

Dominguez, Orlando ;

Martinez, Dolores ;

Manzanares, Miguel ;

Ortega, Sagrario ;

Serrano, Manuel .

NATURE, 2013, 502 (7471) :340-+

[2]

[Anonymous], 1996, REVERSING HUMAN AGIN

[3] The once and future gene therapy [J].

Bulaklak, Karen ;

Gersbach, Charles A. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[4] Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice [J].

Chen, Yanpu ;

Luttmann, Felipe F. ;

Schoger, Eric ;

Schoeler, Hans R. ;

Zelarayan, Laura C. ;

Kim, Kee-Pyo ;

Haigh, Jody J. ;

Kim, Johnny ;

Braun, Thomas .

SCIENCE, 2021, 373 (6562) :1537-+

[5] The Business of Anti-Aging Science [J].

de Magalhaes, Joao Pedro ;

Stevens, Michael ;

Thornton, Daniel .

TRENDS IN BIOTECHNOLOGY, 2017, 35 (11) :1062-1073

[6] The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm [J].

Gems, David ;

de Magalha, Pedro Joao .

AGEING RESEARCH REVIEWS, 2021, 70

[7]

Gill D, 2021, bioRxiv, DOI [10.1101/2021.01.15.426786, 10.1101/2021.01.15.426786, DOI 10.1101/2021.01.15.426786]

[8] DNA methylation-based biomarkers and the epigenetic clock theory of ageing [J].

Horvath, Steve ;

Raj, Kenneth .

NATURE REVIEWS GENETICS, 2018, 19 (06) :371-384

[9]

Klein Bruce J., 2004, SCI CONQUEST DEATH E

[10] Reprogramming to recover youthful epigenetic information and restore vision [J].

Lu, Yuancheng ;

Brommer, Benedikt ;

Tian, Xiao ;

Krishnan, Anitha ;

Meer, Margarita ;

Wang, Chen ;

Vera, Daniel L. ;

Zeng, Qiurui ;

Yu, Doudou ;

Bonkowski, Michael S. ;

Yang, Jae-Hyun ;

Zhou, Songlin ;

Hoffmann, Emma M. ;

Karg, Margarete M. ;

Schultz, Michael B. ;

Kane, Alice E. ;

Davidsohn, Noah ;

Korobkina, Ekaterina ;

Chwalek, Karolina ;

Rajman, Luis A. ;

Church, George M. ;

Hochedlinger, Konrad ;

Gladyshev, Vadim N. ;

Horvath, Steve ;

Levine, Morgan E. ;

Gregory-Ksander, Meredith S. ;

Ksander, Bruce R. ;

He, Zhigang ;

Sinclair, David A. .

NATURE, 2020, 588 (7836) :124-129

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