New-onset Type 1 Diabetes after COVID-19 mRNA Vaccination

被引：44

作者：

Yano, Masahiro ^{[1
]}

Morioka, Tomoaki ^{[1
]}

Natsuki, Yuka ^{[1
]}

Sasaki, Keyaki ^{[1
]}

Kakutani, Yoshinori ^{[1
]}

Ochi, Akinobu ^{[1
]}

Yamazaki, Yuko ^{[1
]}

Shoji, Tetsuo ^{[2
]}

Emoto, Masanori ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Metab Endocrinol & Mol Med, Osaka, Japan

[2] Osaka City Univ, Grad Sch Med, Dept Vasc Med, Osaka, Japan

来源：

INTERNAL MEDICINE | 2022年 / 61卷 / 08期

关键词：

COVID-19; SARS-CoV-2; mRNA vaccine; hyperglycemia; type; 1; diabetes; autoimmunity;

D O I：

10.2169/internalmedicine.9004-21

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is critical to ensure the safety of COVID-19 vaccines. We herein report a 51-year-old Japanese woman who developed acute-onset type 1 diabetes with diabetic ketoacidosis six weeks after receiving the first dose of a COVID-19 messenger ribonucleic acid (mRNA) vaccine. Laboratory tests indicated exhaustion of endogenous insulin secretion, a positive result for insulin autoantibody, and latent thyroid autoimmunity. Human leukocyte antigen typing was homozygous for DRB1*09:01-DQB1*03:03 haplotypes. This case suggests that COVID-19 vaccination can induce type 1 diabetes in some individuals with a genetic predisposition.

引用

页码：1197 / 1200

页数：4

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