Facile and chemoselective reduction of carboxylic acids to alcohols using BOP reagent and sodium borohydride

被引：66

作者：

McGeary, RP ^{[1
]}

机构：

[1] Univ Queensland, Ctr Drug Design & Dev, Brisbane, Qld 4072, Australia

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 20期

关键词：

alcohols; carboxylic acids and derivatives; reduction;

D O I：

10.1016/S0040-4039(98)00480-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydroxybenzotriazolyl esters, formed in situ from carboxylic acids and BOP reagent, react with sodium borohydride in THF to give alcohols in high yields. This method is convenient, rapid and chemoselective, with such functional groups as nitro, halide, nitrile, azido and ester being unaffected, (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3319 / 3322

页数：4

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