Generation of Amyloid-β Peptides by γ-Secretase

被引：1

作者：

Aguayo-Ortiz, Rodrigo ^{[1
]}

Dominguez, Laura ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Dept Fis Quim, Mexico City 04510, DF, Mexico

来源：

ISRAEL JOURNAL OF CHEMISTRY | 2017年 / 57卷 / 7-8期

关键词：

Alzheimer's disease; amyloid beta-peptides; amyloid precursor protein; enzymes; gamma-secretase; FAMILIAL ALZHEIMERS-DISEASE; PRECURSOR PROTEIN APP; A-BETA; PRESENILIN-1; MUTATION; TRANSMEMBRANE DOMAIN; TRANSGENIC MICE; ION CHANNELS; ENDOPLASMIC-RETICULUM; INTRACELLULAR DOMAIN; RELATIVE PROPORTION;

D O I：

10.1002/ijch.201600073

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

gamma-Secretase is a four-component membrane-embedded aspartyl protease involved in the final cleavage step of the amyloid precursor protein (APP) to generate the amyloid-beta (A beta) peptide. Different amino-acid lengths of A beta peptide can be produced by this enzyme, of which the oligomerization and aberrant accumulation of the product containing 42 amino acids (A beta 42) has been associated with the development and formation of amyloid-beta plaques in the brain of Alzheimer's disease (AD) patients. Herein, we review some of the most important topics associated with the structure and activity of gamma-secretase and the factors that alter the substrate cleavage pattern, critical to the formation of the different isoforms of the amyloid-beta peptides.

引用

页码：574 / 585

页数：12

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