TRAIL, Wnt, Sonic Hedgehog, TGFβ, and miRNA Signalings Are Potential Targets for Oral Cancer Therapy

被引：24

作者：

Farooqi, Ammad Ahmad ^{[1
]}

Shu, Chih-Wen ^{[2
]}

Huang, Hurng-Wern ^{[3
]}

Wang, Hui-Ru ^{[3
]}

Chang, Yung-Ting ^{[4
,5
]}

Fayyaz, Sundas ^{[6
]}

Yuan, Shyng-Shiou F. ^{[7
,8
]}

Tang, Jen-Yang ^{[9
,10
,11
]}

Chang, Hsueh-Wei ^{[7
,12
,13
,14
,15
,16
]}

机构：

[1] IBGE, Islamabad 54000, Pakistan

[2] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 81362, Taiwan

[3] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung 80424, Taiwan

[4] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 80424, Taiwan

[5] Acad Sinica, Doctoral Degree Program Marine Biotechnol, Taipei 11529, Taiwan

[6] Rashid Latif Med Coll, Lab Translat Oncol & Personalized Med, Lahore 44000, Pakistan

[7] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Canc Ctr, Kaohsiung 80708, Taiwan

[8] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Translat Res Ctr, Kaohsiung 80708, Taiwan

[9] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Radiat Oncol, Kaohsiung 80708, Taiwan

[10] Kaohsiung Med Univ Hosp, Dept Radiat Oncol, Kaohsiung 80708, Taiwan

[11] Kaohsiung Municipal Tatung Hosp, Dept Radiat Oncol, Kaohsiung 80145, Taiwan

[12] Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Kaohsiung 80424, Taiwan

[13] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 80708, Taiwan

[14] Kaohsiung Med Univ, Kaohsiung 80708, Taiwan

[15] Kaohsiung Med Univ, Res Ctr Nat Prod & Drug Dev, Kaohsiung 80708, Taiwan

[16] Kaohsiung Med Univ, Dept Biomed Sci & Environm Biol, Kaohsiung 80708, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 07期

关键词：

TRAIL; Wnt; sonic hedgehog; TGF beta; miRNA; target therapy; oral cancer; SQUAMOUS-CELL CARCINOMA; APOPTOSIS-INDUCING LIGAND; DEATH RECEPTOR 5; ENDOPLASMIC-RETICULUM STRESS; EPITHELIAL-MESENCHYMAL TRANSITION; NEGATIVE BREAST-CANCER; GROWTH-FACTOR-BETA; OXIDATIVE STRESS; STEM-CELLS; UP-REGULATION;

D O I：

10.3390/ijms18071523

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

linical studies and cancer cell models emphasize the importance of targeting therapies for oral cancer. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is highly expressed in cancer, and is a selective killing ligand for oral cancer. Signaling proteins in the wingless-type mouse mammary tumor virus (MMTV) integration site family (Wnt), Sonic hedgehog (SHH), and transforming growth factor beta (TGF beta) pathways may regulate cell proliferation, migration, and apoptosis. Accordingly, the genes encoding these signaling proteins are potential targets for oral cancer therapy. In this review, we focus on recent advances in targeting therapies for oral cancer and discuss the gene targets within TRAIL, Wnt, SHH, and TGF beta signaling for oral cancer therapies. Oncogenic microRNAs (miRNAs) and tumor suppressor miRNAs targeting the genes encoding these signaling proteins are summarized, and the interactions between Wnt, SHH, TGF beta, and miRNAs are interpreted. With suitable combination treatments, synergistic effects are expected to improve targeting therapies for oral cancer.

引用

页数：21

共 157 条

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