Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape

被引：279

作者：

Garg, Abhishek D. ^{[1
]}

Coulie, Pierre G. ^{[2
]}

Van den Eynde, Benoit J. ^{[3
]}

Agostinis, Patrizia ^{[1
]}

机构：

[1] KU Leuven Univ Leuven, Dept Cellular Mol Med, Cell Death Res & Therapy CDRT Lab, Leuven, Belgium

[2] Catholic Univ Louvain, De Duve Inst, Brussels, Belgium

[3] Catholic Univ Louvain, Ludwig Inst Canc Res, De Duve Inst, WELBIO, Brussels, Belgium

来源：

TRENDS IN IMMUNOLOGY | 2017年 / 38卷 / 08期

关键词：

IMMUNE-CHECKPOINT INHIBITORS; ADVANCED MELANOMA; CLINICAL-TRIALS; TUMOR-CELLS; LYMPH-NODES; SEMI-MATURE; T-CELLS; NIVOLUMAB; RESISTANCE; VACCINATION;

D O I：

10.1016/j.it.2017.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cancer immunotherapy is experiencing a renaissance spearheaded by immune checkpoint inhibitors (ICIs). This has spurred interest in 'upgrading' existing immunotherapies that previously experienced only sporadic success, such as dendritic cells (DCs) vaccines. In this review, we discuss the major molecular, immunological, and clinical determinants of existing first- and second-generation DC vaccines. We also outline the future trends for next-generation DC vaccines and describe their major hallmarks and prerequisites necessary for high anticancer efficacy. In addition, using existing data we compare DC vaccines with ICIs targeting CTLA4, PD1, and PD-L1, and argue that in various contexts next-generation DC vaccines are ready to meet some challenges currently confronting ICIs, thereby raising the need to integrate DC vaccines in future combinatorial immunotherapy regimens.

引用

页码：577 / 593

页数：17

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