Prevalence and Clinical Correlates of Comorbid Anxiety and Panic Disorders in Patients with Parkinson's Disease

被引：10

作者：

Elefante, Camilla ^{[1
]}

Brancati, Giulio Emilio ^{[1
]}

Bacciardi, Silvia ^{[1
]}

Mazzucchi, Sonia ^{[2
]}

Del Prete, Eleonora ^{[2
]}

Palermo, Giovanni ^{[2
]}

Frosini, Daniela ^{[2
]}

Bonuccelli, Ubaldo ^{[2
]}

Ceravolo, Roberto ^{[2
]}

Lattanzi, Lorenzo ^{[1
]}

Maremmani, Icro ^{[1
]}

Perugi, Giulio ^{[1
]}

机构：

[1] Univ Pisa, Santa Chiara Univ Hosp, Dept Clin & Expt Med, Psychiat Unit 2, I-56100 Pisa, Italy

[2] Univ Pisa, Santa Chiara Univ Hosp, Dept Clin & Expt Med, Neurol Unit, I-56100 Pisa, Italy

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 11期

关键词：

Parkinson disease; movement disorder; neurodegenerative diseases; anxiety disorders; panic disorder; mood disorders; QUALITY-OF-LIFE; PSYCHIATRIC COMORBIDITY; DIAGNOSTIC-CRITERIA; NONMOTOR SYMPTOMS; OLDER-ADULTS; DSM-IV; DEPRESSION; VALIDATION; SCALE; SYMPTOMATOLOGY;

D O I：

10.3390/jcm10112302

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mood and anxiety disorders are the most common neuropsychiatric syndromes associated with Parkinson's disease (PD). The aim of our study was to estimate the prevalence of lifetime and current anxiety disorders in patients with Parkinson's Disease (PD), to explore possible distinctive neurological and psychiatric features associated with such comorbidity. One hundred patients were consecutively recruited at the Movement Disorders Section of the Neurological Outpatient Clinic of the University of Pisa. According to the MINI-Plus 5.0.0, 41 subjects were diagnosed with lifetime anxiety disorder (22 with panic disorder) and 26 were diagnosed with current anxiety disorders. Patients with anxiety disorders were more frequently characterized by psychiatric symptoms preceding PD, lifetime major depression and antidepressant treatments. They showed more anxious temperamental traits and scored higher at Parkinson Anxiety Scale (PAS) and persistent anxiety subscale. Current anxiety disorders were associated with more severe psychopathology, depressive symptomatology, and avoidant behavior. Among anxiety subtypes, patients with lifetime panic disorder showed higher rates of psychiatric symptoms before PD, lifetime unipolar depression, current psychiatric treatment, and a more severe psychopathology. Given the overall high impact of anxiety on patients' quality of life, clinicians should not underestimate the extent of different anxiety dimensions in PD.

引用

页数：15

共 64 条

[31] The Parkinson Anxiety Scale (PAS): Development and Validation of a New Anxiety Scale [J].