Renal Oxygenation in the Pathophysiology of Chronic Kidney Disease

被引：33
作者：
Liu, Zhi Zhao [1 ]
Bullen, Alexander [1 ]
Li, Ying [1 ]
Singh, Prabhleen [1 ]
机构：
[1] Univ Calif San Diego, Sch Med, Div Nephrol Hypertens, VA San Diego Healthcare Syst, San Diego, CA 92103 USA
来源：
FRONTIERS IN PHYSIOLOGY | 2017年 / 8卷
关键词：
hypoxia; renal oxygen consumption; hypoxia inducible factor (HIF); AMPK; chronic kidney disease pathophysiology; HYPOXIA-INDUCIBLE FACTOR; ACTIVATED PROTEIN-KINASE; RENIN-ANGIOTENSIN SYSTEM; RAT REMNANT KIDNEY; DIABETIC-NEPHROPATHY; BOLD-MRI; TUBULOINTERSTITIAL INJURY; TUBULOGLOMERULAR FEEDBACK; SUBTOTAL NEPHRECTOMY; OXIDATIVE STRESS;
D O I：
10.3389/fphys.2017.00385
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Chronic kidney disease (CKD) is a significant health problem associated with high morbidity and mortality. Despite significant research into various pathways involved in the pathophysiology of CKD, the therapeutic options are limited in diabetes and hypertension induced CKD to blood pressure control, hyperglycemia management (in diabetic nephropathy) and reduction of proteinuria, mainly with renin-angiotensin blockade therapy. Recently, renal oxygenation in pathophysiology of CKD progression has received a lot of interest. Several advances have been made in our understanding of the determinants and regulators of renal oxygenation in normal and diseased kidneys. The goal of this review is to discuss the alterations in renal oxygenation (delivery, consumption and tissue oxygen tension) in pre-clinical and clinical studies in diabetic and hypertensive CKD along with the underlying mechanisms and potential therapeutic options.
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页数：9
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