Factors associated with perceived loss of libido in people who inject opioids: Results from a community-based survey in France

被引:9
作者
Madrid, Laelia Briand [1 ,2 ]
Morel, Stephane [3 ]
Ndiaye, Khadim [1 ,2 ]
Mezaache, Salim [1 ,2 ]
Castro, Daniela Rojas [1 ,3 ,4 ,5 ]
Mora, Marion [1 ,2 ]
Olivet, Fabrice [6 ]
Laporte, Virginie [3 ]
Protopopescu, Camelia [1 ,2 ]
Carrieri, Patrizia [1 ,2 ]
Roux, Perrine [1 ,2 ]
机构
[1] Aix Marseille Univ, INSERM, IRD, SESSTIM,Fac Med, 27 Blvd Jean Moulin, F-13385 Marseille, France
[2] ORS PACA, Fac Med, 27 Blvd Jean Moulin, F-13385 Marseille, France
[3] AIDES, 14 Rue Scandicci, F-93508 Pantin, France
[4] Univ Lyon 2, Grp Rech Psychol Sociale EA 4163, 5 Ave Pierre Mendes France, F-69676 Bron, France
[5] Coalit Plus, 14 Rue Scandicci, F-93508 Pantin, France
[6] ASUD, 32 Rue Vitruve, F-75020 Paris, France
关键词
Opioid agonist treatment; Opioid use; Sexual dysfunction; Web self-administration surveys; Sensitive questions; METHADONE-MAINTENANCE TREATMENT; QUALITY-OF-LIFE; MEN RECEIVING METHADONE; BUPRENORPHINE MAINTENANCE; SEXUAL DYSFUNCTION; ERECTILE DYSFUNCTION; PREMATURE EJACULATION; PLASMA TESTOSTERONE; DRUG-ABUSE; HEROIN;
D O I
10.1016/j.drugalcdep.2018.05.030
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background - Regular consumption of opioids exposes individuals to several side effects. One of these is a loss of libido, which has a negative impact on quality of life. We used a cross-sectional community-based survey of people who inject opioids to study factors associated with loss of libido, and more particularly the impact of the type of opioid injected. Methods: This secondary study was conducted throughout France in 2015 and involved 514 people who inject opioids. Self-reported sociodemographic characteristics, drug consumption, injection-related data and loss of libido were collected using a brief questionnaire administered either through face-to-face interviews or online. Two different models were used to identify factors associated with loss of libido: simple logistic regression and a two-step Heckman model. Results: Forty-three percent of the participants reported a loss of libido. The first model showed that filling in the questionnaire online (OR[95%CI] = 2.55[1.64;3.96]; p < 0.001), reporting that morphine sulfate (OR [95%CI] = 2.67[1.56;4.58]; p < 0.001) or methadone (OR[95%CI] = 2.50[1.13;5.56]; p = 0.030) was the opioid they injected most (versus buprenorphine), and reporting benzodiazepine use (OR [95%CI] = 1.62[1.07;2.44]; p = 0.033) were factors strongly associated with loss of libido. In the two-step, Heckman model which corrected for selection bias, along with these factors, reporting heroin as the opioid injected most was also strongly associated. Conclusion: Our findings showed that full-opioid agonists could have a negative impact on libido when injected regularly. Libido can improve quality of life and should be routinely discussed through counseling in prevention services with people who inject drugs.
引用
收藏
页码:121 / 127
页数:7
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